{
  "abstract": "Background: Alcohol use disorder is characterized by continued alcohol use despite negative consequences, also known as aversion-resistant drinking. Alcohol related cues can invigorate motivation to seek and consume alcohol. It is currently unknown whether alcohol related cues can invigorate drinking despite negative consequences. Materials and Methods: Long-Evans rats were trained in a discriminative stimulus (DS) task with cues predicting the available of alcohol reward. They were then tested in the task for aversion-resistant drinking by measuring consumption of alcohol adulterated with increasing concentrations of quinine. As a control for an environment free of reward-related cues, rats were also tested for aversion-resistant drinking in the home cage. Results: We found that rats displayed robust aversion-resistant drinking in the DS task. When we compared alcohol consumption in the task with home cage consumption, we found that rats were more aversion-resistant in the task than in the home cage. We also found that individual differences in aversion-resistant drinking were correlated within behavioral context (i.e. home cage or DS task) but not between the home cage and the DS task. Conclusions: We found that aversion-resistant drinking is invigorated during cue-induced alcohol seeking relative to free drinking without explicit cues. Home cage quinine-sensitivity is unrelated to quinine-sensitivity in the presence of cues. This suggests that cues motivate drinking despite negative consequences in a way that is unique from aversion-resistance driven by drinking history. While many behavioral measures use cues and ultimately test aversion-resistant drinking, this is the first explicit test of cue-evoked aversion-resistant drinking.",
  "abstract_shown": true,
  "affiliations": [
    "University of Minnesota"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "M. R. Bauer"
    },
    {
      "name": "J. M. Richard"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b18rqvvngq839.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.07.14.738545",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.07.14.738545v2.full",
  "id": "b18rqvvngq839",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.07.14.738545v2",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2804|Neurotransmitter Receptor Influence on Behavior"
    ]
  ],
  "openalex": "W7169813496",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.07.14.738545v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b18rqvvngq839.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:51Z",
      "native_id": "10.64898/2026.07.14.738545",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.07.14.738545v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Alcohol Cues Invigorate Aversion-Resistant Alcohol Drinking",
  "title_text": "Alcohol Cues Invigorate Aversion-Resistant Alcohol Drinking",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:51Z",
  "url": "https://research.draconitic.com/paper/b18rqvvngq839",
  "venue": "bioRxiv",
  "versions": []
}