{
  "abstract": "Edwardsiella tarda is an opportunistic aquatic pathogen that rarely causes human bacteremia, but it carries high mortality, particularly in immunocompromised hosts. We report the fatal case of a 74-year-old man with refractory multiple myeloma (MM) and profound iatrogenic immunodeficiency who developed septic shock shortly after acquiring tropical fish. Despite the isolate's susceptibility to administered broad-spectrum antibiotics, including meropenem, the patient died within 72 hours of admission. This report highlights the lethal synergy between modern anti-myeloma therapies, specifically the cumulative immunosuppression from proteasome inhibitors, immunomodulatory drugs, anti-CD38 monoclonal antibodies, and the virulence factors of E. tarda. We provide a detailed clinical course and comparative discussion of hematological cases in Japan. This case underscores the critical need for thorough environmental history-taking and specific counseling for profoundly immunocompromised patients regarding the risks of exotic pet ownership.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Yuka Tanaka"
    },
    {
      "name": "Keita Sugihara"
    },
    {
      "name": "Ryota Minami"
    },
    {
      "name": "Mioka Matsumoto"
    },
    {
      "name": "Norimitsu Saitoh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b1b4s1w7zaqwg.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.6545-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6545-25/_article",
  "id": "b1b4s1w7zaqwg",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6545-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "1310|Infections and bacterial resistance"
    ]
  ],
  "openalex": "W7143469408",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6545-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b1b4s1w7zaqwg.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:20:57Z",
      "native_id": "10.2169/internalmedicine.6545-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/21/65_6545-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1310|Infections and bacterial resistance",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Fatal Edwardsiella tarda Sepsis in a Patient with End-stage Multiple Myeloma: A Case of Suspected Zoonotic Transmission",
  "title_text": "Fatal Edwardsiella tarda Sepsis in a Patient with End-stage Multiple Myeloma: A Case of Suspected Zoonotic Transmission",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:33Z",
  "url": "https://research.draconitic.com/paper/b1b4s1w7zaqwg",
  "venue": "Internal Medicine",
  "versions": []
}