{
  "abstract": "Purpose\n\nThe Naples Prognostic Score (NPS) is a widely recognized scoring system used to assess inflammation and nutrition status, yet its role in prostate cancer (PCa) remains unclear. This study aims to investigate the association between the modified NPS (MNPS) and PCa prevalence and mortality outcomes among participants with self-reported PCa.Methods\n\nData from the National Health and Nutrition Examination Survey 1999-2018 were collected. The NPS was calculated using MaxStat analysis, while M1NPS and M2NPS were constructed with X-Tile analysis. Weighted logistic regression was used to estimate the odds ratio (OR) for PCa prevalence. Kaplan-Meier survival analysis, log-rank tests, and Cox proportional hazard ratios (HR) were employed to analyze the mortality risk.Results\n\nAmong 22,027 individuals, 717 had PCa. After considering the interactions among different factors and adjusting for confounding variables, the prevalence of PCa was notably higher in participants with the highest MNPS groups (group 3) compared with those with the lowest groups (group 1) (OR (95% CI) = 2.96 (1.57-5.57) for M1NPS; 15.50 (1.78-134.71) for M2NPS). With a median follow-up of 9.92 years, 326 (45.47%) of all-cause deaths occurred among participants with self-reported PCa. Significant differences in all-cause mortality were observed between the MNPS groups (log-rank P < 0.001 for M1NPS and M2NPS). Compared to participants with self-reported PCa in group 1, the adjusted HRs for all-cause mortality in group 3 were 1.12 (95% CI: 0.49-2.57) for M1NPS and 2.02 (95% CI: 1.19-3.44) for M2NPS. Furthermore, a significant association was found between M2NPS and cardiovascular mortality (HR (95% CI) = 4.77 (1.95-11.65).Conclusion\n\nThe modified and optimized NPS, which integrates inflammation and nutritional status, is associated with PCa prevalence and with all-cause and cardiovascular mortality among individuals with self-reported PCa.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.",
    "Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.",
    "Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. zhouyixh@sina.com.",
    "Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. pumchywg@sina.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hong Zeng"
    },
    {
      "affs": [
        0
      ],
      "name": "Fan Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Qian Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Tianyi Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Junhao Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Shijie Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Tianrui Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhen Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuliang Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiwei Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Chenhui Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhien Zhou"
    },
    {
      "affs": [
        2
      ],
      "name": "Yi Zhou"
    },
    {
      "affs": [
        3
      ],
      "name": "Weigang Yan",
      "orcid": "0000-0002-8995-1456"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b1jrsyp723v5c.bib",
  "cited_by": 0,
  "doi": "10.1186/s41043-026-01402-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13685192",
  "id": "b1jrsyp723v5c",
  "issns": [
    "1606-0997",
    "2072-1315"
  ],
  "landing_url": "https://europepmc.org/article/MED/42902334",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RA1-1270"
    ],
    [
      "lcc",
      "RC620-627"
    ],
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
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  "openalex": "W7170741642",
  "pdf_url": "https://europepmc.org/articles/PMC13685192?pdf=render",
  "pmcid": "PMC13685192",
  "pmid": "42902334",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/b1jrsyp723v5c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42902334",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42902334"
    },
    {
      "first_seen": "2026-10-30T13:46:06Z",
      "native_id": "c664e0fd383c46849db77054f7d00c4f",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "The clinical significance of the modified Naples prognostic score for prostate cancer: a population-based study.",
  "title_text": "The clinical significance of the modified Naples prognostic score for prostate cancer: a population-based study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:06Z",
  "url": "https://research.draconitic.com/paper/b1jrsyp723v5c",
  "venue": "Journal of health, population, and nutrition",
  "versions": []
}