{
  "abstract": "Introduction and Objectives: Acute kidney injury (AKI) is a serious complication in decompensated cirrhosis (DC). Conventional kidney function markers, including serum creatinine (sCr) and estimated glomerular filtration rate (eGFR), are often inaccurate in these patients. We aimed to develop a predictive model for AKI using routine admission data. Patients and Methods: We retrospectively analyzed patients with DC and normal sCr admitted to a local tertiary hospital (Dec 2016-Dec 2022). AKI was defined per International Club of Ascites criteria. Predictors were selected using the least absolute shrinkage and selection operator regression and incorporated into a logistic model, internally validated via enhanced bootstrap and externally validated in the MIMIC-III cohort. Model performance was assessed using AUROC, calibration, and decision curve analysis (DCA). A user-friendly nomogram was constructed. Results: Of 1863 patients screened, 1091 met criteria; 122 (10.8%) developed AKI. AKI patients were older, had longer stays, worse liver function, more complications (hepatic encephalopathy, infections), and higher rates of hypertension (HT) and type 2 diabetes mellitus (DM2). sCr and eGFR had poor discrimination for AKI. The final model included age, neutrophil count, direct bilirubin, Child-Turcotte-Pugh score, DM2, and HT, achieving AUROC 0.755 (internal validation: AUROC 0.733, sensitivity 0.697, specificity 0.626). DCA showed greater clinical benefit than treat-all or treat-none strategies. External validation in 810 MIMIC-III patients yielded AUROC 0.729; bootstrap validation confirmed robustness (AUROC 0.752, sensitivity 0.748, specificity 0.677). Conclusions: We developed and validated a simple admission-based model for predicting AKI in DC, supporting its potential use for risk stratification and early intervention.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Severe Hepatopathy, Mengchao Hepatobiliary Hospital of Fujian Medical University, No.66 Jintang Road, Jianxin Town, Cangshan District, Fuzhou, Fujian 350028, China",
    "Department of Infectious Disease, Pingtan Branch of Fujian Medical University Union Hospital, Pingtan, Fujian 350400, China; Department of Infectious Disease, Fujian Pingtan Comprehensive Experimental Zone Hospital, Pingtan, Fujian 350400, China",
    "Department of Severe Hepatopathy, Mengchao Hepatobiliary Hospital of Fujian Medical University, No.66 Jintang Road, Jianxin Town, Cangshan District, Fuzhou, Fujian 350028, China; The Clinical School of Fujian Medical University, Fuzhou, Fujian 350001, China",
    "Department of Severe Hepatopathy, Mengchao Hepatobiliary Hospital of Fujian Medical University, No.66 Jintang Road, Jianxin Town, Cangshan District, Fuzhou, Fujian 350028, China; Corresponding author."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shenglong Lin"
    },
    {
      "affs": [
        1
      ],
      "name": "Wenhai Ke"
    },
    {
      "affs": [
        2
      ],
      "name": "Rong Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Huaxi Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Ziyuan Liao"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianyu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Minghua Lin"
    },
    {
      "affs": [
        3
      ],
      "name": "Haibing Gao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b258rqe4mdh9z.bib",
  "cited_by": 0,
  "doi": "10.1016/j.aohep.2026.102223",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S166526812600044X",
  "id": "b258rqe4mdh9z",
  "issns": [
    "1665-2681",
    "2659-5982"
  ],
  "landing_url": "https://doi.org/10.1016/j.aohep.2026.102223",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC581-951"
    ],
    [
      "openalex",
      "2721|Liver Disease and Transplantation"
    ]
  ],
  "openalex": "W7160930863",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/b258rqe4mdh9z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:58Z",
      "native_id": "c79f0d08535246c4859c373e360e162b",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.aohep.2026.102223"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver Disease and Transplantation",
      "subfield": "general"
    }
  ],
  "title": "Development and validation of a prediction model for acute kidney injury in cirrhosis with normal serum creatinine levels",
  "title_text": "Development and validation of a prediction model for acute kidney injury in cirrhosis with normal serum creatinine levels",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:58Z",
  "url": "https://research.draconitic.com/paper/b258rqe4mdh9z",
  "venue": "Annals of Hepatology",
  "versions": []
}