{
  "abstract": "Human T cell leukemia virus type 1 (HTLV-1)-associated inflammation, including uveitis, lacks effective targeted therapies. Here, we investigated whether epigenetic modulation through EZH1/2 inhibition could influence HTLV-1-related ocular inflammation using in vitro co-culture and infection models. HTLV-1 exposure increased EZH1 and EZH2 expression and the repressive histone mark H3K27me3 in retinal pigment epithelial cells. Treatment with the dual EZH1/2 inhibitor valemetostat reduced H3K27me3 levels. Valemetostat showed limited effects on cell viability and induced only modest, context-dependent apoptosis. Virological analyses showed model-dependent changes in proviral load, accompanied by reduced viral gene expression. Profiling of cytokines and chemokines revealed context-dependent modulation of inflammatory mediators. Functional assessment using p65 nuclear translocation assays indicated partial attenuation of NF-κB activation under inflammatory stimulation. Collectively, these findings suggest that EZH1/2-mediated epigenetic regulation is primarily involved in HTLV-1-related inflammatory responses, and that inhibiting EZH1/2 may be a potential approach to modulate inflammatory signaling.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Yaru Zou"
    },
    {
      "name": "Koju Kamoi"
    },
    {
      "name": "Mingming Yang"
    },
    {
      "name": "Yuan Zong"
    },
    {
      "name": "Jing Zhang"
    },
    {
      "name": "Kyoko Ohno-Matsui"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b25cegdrnghp9.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117775",
  "fulltext_url": "https://europepmc.org/articles/PMC13677313",
  "id": "b25cegdrnghp9",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03156-1",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Biological sciences"
    ],
    [
      "heading",
      "Cell biology"
    ],
    [
      "heading",
      "Molecular biology"
    ],
    [
      "openalex",
      "2403|T-cell and Retrovirus Studies"
    ]
  ],
  "openalex": "W7221068718",
  "pdf_url": "https://europepmc.org/articles/PMC13677313?pdf=render",
  "pmcid": "PMC13677313",
  "pmid": "42898112",
  "published": "2026-10-08",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/b25cegdrnghp9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117775",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03156-1"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117775",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226031561"
    },
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42898112",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898112"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "heading:Molecular biology",
      "subfield": "molecular-biology"
    },
    {
      "field": "biology",
      "origin": "heading:Cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "Dual impact of EZH1/2-targeted therapy in HTLV-1-associated inflammation: Direct and indirect mechanisms",
  "title_text": "Dual impact of EZH1/2-targeted therapy in HTLV-1-associated inflammation: Direct and indirect mechanisms",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/b25cegdrnghp9",
  "venue": "iScience",
  "versions": []
}