{
  "abstract": "Marine macroalgae are widely distributed renewable resources that offer substantial economic and environmental benefits. This review comprehensively examines seaweeds from the phyla Chlorophyta, Heterokontophyta, and Rhodophyta, highlighting key advances and persistent challenges. Global seaweed production is highly concentrated: Asia accounts for 97% of the total, with China as the dominant producer. These seaweeds synthesize a diverse array of bioactive compounds, including sulfated polysaccharides, phlorotannins, terpenoids, proteins, peptides, polyunsaturated fatty acids, and pigments. Notably, brown algae represent the richest source of both phlorotannins and polyunsaturated fatty acids. To recover these valuable compounds efficiently, a range of advanced green extraction techniques have been developed, such as enzyme-assisted, microwave-assisted, ultrasound-assisted, and supercritical fluid extraction, along with natural deep eutectic solvents. These methods consistently outperform conventional approaches in terms of yield, extraction time, and environmental sustainability. The isolated compounds exhibit a broad spectrum of validated pharmacological activities, including immunomodulatory, anti-inflammatory, anti-diabetic, neuroprotective, antitumor, and antiviral effects. Consequently, they have found diverse applications in functional foods, biomedicine, cosmetics, agriculture, aquaculture, and environmental protection. Despite this promise, critical challenges remain in elucidating structure-activity relationships, developing scalable and sustainable extraction protocols, and advancing clinical translation. Future research should prioritize the discovery of novel marine bioactives, the enzymatic production of oligosaccharides, efficient purification of algal proteins and peptides, and the scaling-up of industrial processes to fully realize the pharmaceutical and biotechnological potential of marine macroalgae.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Mariculture Breeding, College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China",
    "School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yongjing Guan",
      "orcid": "0009-0005-0924-3230"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuxin Guo",
      "orcid": "0000-0003-4138-5106"
    },
    {
      "affs": [
        0
      ],
      "name": "Luoxuan Lin"
    },
    {
      "affs": [
        1
      ],
      "name": "Lizhu Zhang",
      "orcid": "0009-0004-9295-5900"
    },
    {
      "affs": [
        0
      ],
      "name": "Weichao Chen",
      "orcid": "0009-0009-4793-7929"
    },
    {
      "affs": [
        0
      ],
      "name": "Chao Zhao",
      "orcid": "0000-0003-1096-632X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b2gq02t8h4mv5.bib",
  "cited_by": 5,
  "doi": "10.3390/md24060198",
  "fulltext_url": null,
  "id": "b2gq02t8h4mv5",
  "issns": [
    "1660-3397"
  ],
  "landing_url": "https://doi.org/10.3390/md24060198",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1104|Seaweed-derived Bioactive Compounds"
    ]
  ],
  "openalex": "W7163524383",
  "pdf_url": null,
  "pmcid": "PMC13301856",
  "pmid": "42346784",
  "published": "2026-06-04",
  "publisher": "Multidisciplinary Digital Publishing Institute",
  "ris": "https://research.draconitic.com/paper/b2gq02t8h4mv5.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T13:20:45Z",
      "native_id": "W7163524383",
      "source": "openalex",
      "url": "https://doi.org/10.3390/md24060198"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1104|Seaweed-derived Bioactive Compounds",
      "subfield": "ecology"
    }
  ],
  "title": "Green Extraction of Bioactive Compounds from Marine Macroalgae: Chemistry, Pharmacological Activities, and Biotechnological Applications",
  "title_text": "Green Extraction of Bioactive Compounds from Marine Macroalgae: Chemistry, Pharmacological Activities, and Biotechnological Applications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:09Z",
  "url": "https://research.draconitic.com/paper/b2gq02t8h4mv5",
  "venue": "Marine Drugs",
  "versions": []
}