{
  "abstract": "Background: Cutaneous melanoma (CM) is an aggressive cancer since early stages. Stage IIB/C CM present significant recurrence risk. Recently, adjuvant immunotherapy demonstrated to increase recurrence-free survival (RFS) in this setting.\n\nObjective: Assess safety and efficacy of adjuvant immunotherapy for stage IIB/C CM in a real-world setting.\n\nMethods: Stage IIB/C CM patients treated with adjuvant immunotherapy in eight centers from the “Gruppo Oncologico Italia Meridionale” (GOIM) were retrospectively investigated. Data were collected over a median follow-up of 16 months.\n\nResults: Ninety-six patients with a median age of 59 years were included. Most participants were male (64.6%). Approximately 60.4% were classified stage IIB and 39.6% stage IIC, with the majority of tumors localized on the trunk (54.2%). Toxicity occurred in 63.5% of patients with 79.7% of these events classified as grade 1–2 (CTCAE v5.0). The most reported events were thyroid dysfunction, fatigue, gastrointestinal disorders and itchiness. Recurrence was observed only in 7 patients (7.3%).\n\nConclusions: The 12-month and 24-month RFS were respectively 98.7% and 82.6%. The toxicity profile was generally manageable in a real-life population, however 17.6% of all patients experienced grade 3–4 AEs, underscoring the importance of evaluating adjuvant therapy in a multidisciplinary setting.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00262-026-04466-0 .",
  "abstract_shown": true,
  "affiliations": [
    "Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy",
    "Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy",
    "Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy",
    "Istituto Tumori IRCCS Giovanni Paolo II, Bari, Italy",
    "Unit of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy",
    "San Paolo Hospital, Bari, Apulia Italy",
    "Department of Human Pathology “G. Barresi”, University of Messina, 98125 Messina, Italy",
    "Oncology Department, Oncology Unit, “Azienda Ospedaliero Universitaria (AOU) Dulbecco” Hospital, Catanzaro, Italy",
    "Medical Oncology Unit, AORN San Pio, Benevento, Italy",
    "Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy",
    "Multidisciplinary Department of Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy",
    "Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IRCCS, Milan, Italy"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 30,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Vincenzo De Falco"
    },
    {
      "affs": [
        0
      ],
      "name": "Antonino Colloca"
    },
    {
      "affs": [
        1
      ],
      "name": "Giuseppe Argenziano"
    },
    {
      "affs": [
        2
      ],
      "name": "Marcella Scala"
    },
    {
      "affs": [
        3
      ],
      "name": "Michele Guida"
    },
    {
      "affs": [
        4
      ],
      "name": "Margaret Ottaviano"
    },
    {
      "affs": [
        5
      ],
      "name": "Maria Chiara Sergi"
    },
    {
      "affs": [
        6
      ],
      "name": "Mariacarmela Santarpia"
    },
    {
      "affs": [
        7
      ],
      "name": "Teresa Del Giudice"
    },
    {
      "affs": [
        8
      ],
      "name": "Antonio Maria Grimaldi"
    },
    {
      "affs": [
        0
      ],
      "name": "Silvana Cozzolino"
    },
    {
      "affs": [
        0
      ],
      "name": "Miriam Forte"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesco Caraglia"
    },
    {
      "affs": [
        0
      ],
      "name": "Eleonora Cioli"
    },
    {
      "affs": [
        0
      ],
      "name": "Alfonso Esposito"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Cristina Giugliano"
    },
    {
      "affs": [
        4
      ],
      "name": "Francesca Sparano"
    },
    {
      "affs": [
        9
      ],
      "name": "Francesco Iovino"
    },
    {
      "affs": [
        9
      ],
      "name": "Salvatore Tolone"
    },
    {
      "affs": [
        9
      ],
      "name": "Giovanni Docimo"
    },
    {
      "affs": [
        10
      ],
      "name": "Giuseppe Colella"
    },
    {
      "affs": [
        10
      ],
      "name": "Mario Faenza"
    },
    {
      "affs": [
        1
      ],
      "name": "Renato Franco"
    },
    {
      "affs": [
        1
      ],
      "name": "Camila Scharf"
    },
    {
      "affs": [
        0
      ],
      "name": "Anna Russo"
    },
    {
      "affs": [
        2
      ],
      "name": "Luigi Formisano"
    },
    {
      "affs": [
        11
      ],
      "name": "Davide Ciardiello"
    },
    {
      "affs": [
        4
      ],
      "name": "Paolo Antonio Ascierto"
    },
    {
      "affs": [
        0
      ],
      "name": "Fortunato Ciardiello"
    },
    {
      "affs": [
        0
      ],
      "name": "Teresa Troiani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b2hs8j9563kwr.bib",
  "cited_by": 0,
  "doi": "10.1007/s00262-026-04466-0",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13719983/",
  "id": "b2hs8j9563kwr",
  "issns": [
    "0340-7004",
    "1432-0851"
  ],
  "landing_url": "https://doi.org/10.1007/s00262-026-04466-0",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
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      "openalex",
      "2730|Cutaneous Melanoma Detection and Management"
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  "openalex": "W7169154953",
  "pdf_url": null,
  "pmcid": "PMC13719983",
  "pmid": "42467079",
  "published": "2026-07-17",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/b2hs8j9563kwr.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:23:51Z",
      "native_id": "PMC13719983",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00262-026-04466-0"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cutaneous Melanoma Detection and Management",
      "subfield": "oncology"
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  ],
  "title": "Adjuvant immunotherapy in high-risk stage II melanoma: real-world outcomes from a large multicenter retrospective study",
  "title_text": "Adjuvant immunotherapy in high-risk stage II melanoma: real-world outcomes from a large multicenter retrospective study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:57Z",
  "url": "https://research.draconitic.com/paper/b2hs8j9563kwr",
  "venue": "Cancer Immunology, Immunotherapy : CII",
  "versions": []
}