{
  "abstract": "Health systems increasingly measure physiological and behavioral outputs, yet the transition from a bodily signal to a safe, feasible decision remains difficult to specify. We propose the Interoceptive Self-Regulation Loop (ISRL), a provisional framework linking context and exposure, bodily state, interoceptive sampling, appraisal, action, and feedback. Four measurement strata distinguish contextual inputs, functional changes, subjective signals, and clinical indicators. A safety gate operates throughout the loop through condition-specific rules, named clinical responsibility, and documented escalation and follow-up. Its purpose is to support decisions without transferring diagnosis or risk assessment to individuals. The proposed contribution is an explicit, testable account of cross-stratum discordance and evidence-responsive appraisal, rather than the invention of interoception, triage, or behavior-change support. We specify independent candidate measures of appraisal flexibility and action proportionality, illustrate the safety gate using recent-onset chest pain, and compare ISRL with a simpler combination of the common-sense model, COM-B, and identical triage guidance. Six propositions distinguish supporting predictions from the more discriminating tests of discordance, flexibility, and timely care. A bounded initial research program concerns adults in primary care, daily observations, and episode-level decisions, with prospective validation before interventional use. Repeated failure to improve prediction or decisions over the active comparator, despite adequate measurement and precision, would count against retaining ISRL as a distinct framework in that setting. Clinical safety, monitoring burden, cultural adaptation, and unequal access are explicit evaluation outcomes. ISRL remains a theory for investigation, not a validated diagnostic tool or treatment.",
  "abstract_shown": true,
  "affiliations": [
    "School of Basic Medical Sciences, Southern Medical University",
    "School of Medicine and Nursing, Shandong Vocational University of Foreign Affairs",
    "Independent Researcher"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Haojie Dai"
    },
    {
      "affs": [
        2
      ],
      "name": "Min Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaohong Gu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b365646z1jgdf.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1981905",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720441/?tool=EBI",
  "id": "b365646z1jgdf",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1981905/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Hypothesis and Theory"
    ],
    [
      "openalex",
      "2714|Clinical Reasoning and Diagnostic Skills"
    ]
  ],
  "openalex": "W7222717592",
  "pdf_url": "https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1981905/pdf",
  "pmcid": "PMC13720441",
  "pmid": "42964653",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/b365646z1jgdf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:24Z",
      "native_id": "10.3389/fpubh.2026.1981905",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1981905/full"
    },
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13720441",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13720441"
    },
    {
      "first_seen": "2026-11-03T12:21:19Z",
      "native_id": "PMC13720441",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fpubh.2026.1981905"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2296-2565",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "From bodily signals to safe action: an interoceptive self-regulation loop for whole-person health",
  "title_text": "From bodily signals to safe action: an interoceptive self-regulation loop for whole-person health",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:19Z",
  "url": "https://research.draconitic.com/paper/b365646z1jgdf",
  "venue": "Frontiers in Public Health",
  "versions": []
}