{
  "abstract": "Glucocorticoids (GCs) are essential endocrine regulators coordinating stress responsiveness, metabolic flexibility, inflammatory resolution, and circadian physiology. While acute GC fluctuations are adaptive, sustained exposure (arising from psychosocial stress, circadian disruption, obesity, chronic inflammation, neoplasms, or steroid therapy) elicits pleiotropic effects that overlap with biological aging. Prolonged GC signaling intersects with multiple hallmarks of aging by altering nutrient sensing, suppressing autophagy, impairing mitochondrial quality control, and promoting cellular senescence. In this context, the GC-responsive polypeptide ACBP/DBI (acyl-coenzyme A [CoA]-binding protein/diazepam-binding inhibitor) has emerged as a stress-induced inhibitor of macroautophagy that amplifies several metabolic and immune consequences of GC excess linked to aging phenotypes. Clinically, chronic GC elevation is associated with earlier and more severe manifestations of age-related diseases, including metabolic syndrome, osteoporosis, sarcopenia, neurodegeneration, cardiovascular disease, immunosenescence, and cancer. Here, we review mechanistic links between GC signaling and systemic aging and discuss strategies to mitigate the age-accelerating consequences of persistent GC exposure.",
  "abstract_shown": true,
  "affiliations": [
    "Université Paris Cité, Sorbonne Université, Inserm U1138, Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Paris, France",
    "Assistance Publique Hôpitaux de Marseille, Department of Endocrinology, La Conception Hospital, Marseille, France",
    "Université Paris Cité, Sorbonne Université, Inserm U1138, Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Paris, France; Facultad de Ciencias de la Vida y la Naturaleza, Universidad Nebrija, Madrid 28248, Spain"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Flavia Lambertucci",
      "orcid": "0000-0002-2719-6635"
    },
    {
      "affs": [
        1
      ],
      "name": "Frédéric Castinetti",
      "orcid": "0000-0002-1808-8800"
    },
    {
      "affs": [
        0
      ],
      "name": "Isabelle Martins",
      "orcid": "0000-0003-0885-613X"
    },
    {
      "affs": [
        2
      ],
      "name": "Carlos López-Otı́n",
      "orcid": "0000-0001-6964-1904"
    },
    {
      "name": "Guido Kroemer",
      "orcid": "0000-0002-9334-4405"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b37gp5ch7a4tr.bib",
  "cited_by": 6,
  "doi": "10.1016/j.cmet.2026.05.002",
  "fulltext_url": null,
  "id": "b37gp5ch7a4tr",
  "issns": [
    "1550-4131",
    "1932-7420"
  ],
  "landing_url": "https://doi.org/10.1016/j.cmet.2026.05.002",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7162692242",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42208534",
  "published": "2026-05-28",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/b37gp5ch7a4tr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:48Z",
      "native_id": "W7162692242",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.cmet.2026.05.002"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "Pro-aging effects of chronic glucocorticoid signaling",
  "title_text": "Pro-aging effects of chronic glucocorticoid signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T13:20:39Z",
  "url": "https://research.draconitic.com/paper/b37gp5ch7a4tr",
  "venue": "Cell Metabolism",
  "versions": []
}