{
  "abstract": "Non-coding RNAs (ncRNAs) regulate antitumor immunity but clinical use is hindered by instability, poor specificity, and immunogenic risk. Lipid nanoparticles (LNPs) offer a promising delivery solution due to biocompatibility, a modifiable surface, and efficient ncRNA encapsulation. Preclinical and early clinical studies have demonstrated the efficacy of LNP-ncRNA therapies in various cancers, including respiratory, digestive, and neurologic malignancies, and in cancer immunotherapy. This review evaluates engineered LNPs administered via different routes, explains the mechanisms that promote antitumor effects, and highlights advances in overcoming delivery barriers to enhance immunotherapy. Current limitations of engineered LNPs are also analyzed, essential translational challenges are identified, and future directions to facilitate the clinical application of LNP-based ncRNA therapies are suggested.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China",
    "Department of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo 315020, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yufei Sheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Lulu Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Boyang Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Wentao Hu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chengwei Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhaohui Gong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b3djcq5y18c10.bib",
  "cited_by": 1,
  "doi": "10.20892/j.issn.2095-3941.2025.0825",
  "fulltext_url": "https://www.cancerbiomed.org/content/23/10/1361",
  "id": "b3djcq5y18c10",
  "issns": [
    "2095-3941"
  ],
  "landing_url": "https://doi.org/10.20892/j.issn.2095-3941.2025.0825",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "1312|RNA Interference and Gene Delivery"
    ]
  ],
  "openalex": "W7152675636",
  "pdf_url": "https://www.cancerbiomed.org/content/cbm/early/2026/04/09/j.issn.2095-3941.2025.0825.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "China Anti-Cancer Association",
  "ris": "https://research.draconitic.com/paper/b3djcq5y18c10.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T14:21:25Z",
      "native_id": "01da3fbf8c1240ad9f3b69e7f85701dc",
      "source": "doaj",
      "url": "https://doi.org/10.20892/j.issn.2095-3941.2025.0825"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|RNA Interference and Gene Delivery",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Non-coding RNA delivery via lipid nanoparticles: a novel strategy for cancer immunotherapy",
  "title_text": "Non-coding RNA delivery via lipid nanoparticles: a novel strategy for cancer immunotherapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T14:20:21Z",
  "url": "https://research.draconitic.com/paper/b3djcq5y18c10",
  "venue": "Cancer Biology & Medicine",
  "versions": []
}