{
  "abstract": "Spinal cord injury (SCI) causes irreversible neural damage and functional impairment. H-RN is a short peptide originating from the kringle 1 domain of hepatocyte growth factor. Despite its efficacy in inhibiting inflammatory responses, the precise neuroprotective mechanisms of the peptide H-RN in SCI remain unclear. The short peptide CAQK can target the lesion epicenter of SCI. To explore the role of the peptide H-RN in SCI and address the numerous challenges faced by conventional drug therapies, this study developed a synthetic peptide, CAQK-H-RN. Our results revealed that CAQK-H-RN could cross the blood-spinal cord barrier, precisely target the SCI region, and increase drug accumulation at the injury site, thereby reducing glial scar formation, decreasing motor neuron death, and enhancing functional recovery after SCI. RNA sequencing was performed to explore the molecular mechanisms of CAQK-H-RN in SCI, which revealed that CAQK-H-RN inhibited pyroptosis and ameliorated lysosomal membrane permeabilization (LMP)-induced autophagic flux disorders in neurons after SCI. Additionally, CAQK-H-RN alleviated LMP by suppressing acid sphingomyelinase activity through the p38 mitogen-activated protein kinase/Ets-like protein-1 (Elk-1)/early growth response protein 1 (Egr-1) signaling cascade and subsequently enhanced autophagy, thereby mitigating neuronal death. This intravenous therapeutic system centered on the synthetic peptide CAQK-H-RN contributes to the functional restoration of SCI, which may be clinically applicable to spinal cord repair.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.",
    "Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China.",
    "Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo 315300, China.",
    "The First Clinical Medical College (School of Information and Engineering), Wenzhou Medical University, Wenzhou 325035, China.",
    "The Second Clinical Medical College of Wenzhou Medical University, Wenzhou 325027, China.",
    "Department of Orthopaedics, Tangdu Hospital, The Air Force Medical University, Xi'an 710038, China.",
    "School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325000, China.",
    "Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.",
    "Department of Orthopedics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.",
    "Department of Wound Repair, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.",
    "Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.",
    "Department of Laboratory Medicine, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu 241001, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuzhe Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jingwei Shi"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ruize Miao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Linyi Xiang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiacheng Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Weiyi Chi"
    },
    {
      "affs": [
        4
      ],
      "name": "Yuheng Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Yibo Geng"
    },
    {
      "affs": [
        6
      ],
      "name": "Xiong Cai"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yun Shu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiayi Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Junsheng Zhu"
    },
    {
      "affs": [
        7
      ],
      "name": "Xiaoqiong Jiang"
    },
    {
      "affs": [
        8
      ],
      "name": "Haojie Zhang"
    },
    {
      "affs": [
        2,
        7,
        9
      ],
      "name": "Zhenglin Li",
      "orcid": "0000-0002-6583-9013"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiangyang Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sunren Sheng"
    },
    {
      "affs": [
        10
      ],
      "name": "Chenchen Zhu",
      "orcid": "0000-0001-9953-7366"
    },
    {
      "affs": [
        11
      ],
      "name": "Jianjun Qi"
    },
    {
      "affs": [
        0,
        2,
        7,
        9
      ],
      "name": "Jian Xiao",
      "orcid": "0000-0001-7374-6506"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Kailiang Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b3mranfeqm0dc.bib",
  "cited_by": 0,
  "doi": "10.34133/bmr.0431",
  "fulltext_url": "https://europepmc.org/articles/PMC13710766",
  "id": "b3mranfeqm0dc",
  "issns": [
    "1226-4601",
    "2055-7124"
  ],
  "landing_url": "https://europepmc.org/article/MED/42947949",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2734|Spinal Cord Injury Research"
    ]
  ],
  "openalex": "W7220428103",
  "pdf_url": "https://europepmc.org/articles/PMC13710766?pdf=render",
  "pmcid": "PMC13710766",
  "pmid": "42947949",
  "published": "2026-10-27",
  "publisher": "AAAS Science Partner Journal Program",
  "ris": "https://research.draconitic.com/paper/b3mranfeqm0dc.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:33Z",
      "native_id": "MED:42947949",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42947949"
    },
    {
      "first_seen": "2026-10-31T12:21:40Z",
      "native_id": "PMC13710766",
      "source": "pmc",
      "url": "https://doi.org/10.34133/bmr.0431"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Spinal Cord Injury Research",
      "subfield": "general"
    }
  ],
  "title": "Glial Scar-Targeted Modification of Hepatocyte Growth Factor-Derived Peptide for Spinal Cord Injury Therapeutic Repair.",
  "title_text": "Glial Scar-Targeted Modification of Hepatocyte Growth Factor-Derived Peptide for Spinal Cord Injury Therapeutic Repair.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:40Z",
  "url": "https://research.draconitic.com/paper/b3mranfeqm0dc",
  "venue": "Biomaterials research",
  "versions": []
}