{ "abstract": "Background\n\nCrohn's disease (CD) is an inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract. Although upper gastrointestinal (UGI) manifestations are well recognized in pediatrics, UGI-CD in adults has historically been underestimated. Methodological limitations, including selective endoscopy and inconsistent classification, have contributed to variable prevalence estimates.Aims\n\nOur goals were to summarize the prevalence of UGI-CD in adults with CD, understand demographic variations, and summarize knowledge gaps.Methods\n\nWe conducted a scoping review of MEDLINE, Embase, and Cochrane CENTRAL (1995-November 2025) using PRISMA-ScR and JBI methodology. Eligible studies reported adult UGI-CD prevalence or related epidemiologic data. Extracted variables included prevalence estimates, site-level involvement, and demographics. Systematic reviews were included to summarize review-level epidemiologic evidence.Results\n\nIn total, 117 primary studies and eight systematic reviews were included. Across 95 cohorts with prevalence data, the median prevalence of UGI-CD was 8.8% (IQR 3.99%-14.5%). Higher rates were observed in cohorts using systematic endoscopy and biopsy, while population-based cohorts reported lower values. Isolated UGI-CD was rare, with a median prevalence of 1.37% (IQR 0.87%-3.02%). Prevalence varied geographically and ethnically, with lowest rates in South Asian cohorts and higher rates in East Asian and Middle Eastern cohorts. Site-specific reporting was inconsistent, and few studies detailed modifiers such as smoking or family history.Conclusions\n\nReported prevalence estimates of adult UGI-CD remain highly variable due to inconsistent definitions and detection strategies. Standardized, site-specific adult definitions and systematic diagnostic protocols are needed to enable cross-study comparisons and thus improve prevalence estimates and address demographic reporting gaps.", "abstract_shown": true, "affiliations": [ "Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.", "Department of Medicine Division of Gastroenterology, Western University, London, ON, Canada.", "Lawson Health Research Institute, London, ON, Canada.", "Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.", "Department of Gastroenterology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.", "Division of Gastroenterology & Hepatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.", "Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.", "Division of Pediatric Gastroenterology, Department of Pediatrics, Children's Hospital Western Ontario, Western University, London, Ontario, Canada.", "Division of Gastroenterology, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.", "Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, Milano, Italy.", "Division of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, Quebec, Canada.", "Department of Gastroenterology, CHRU Nancy, INSERM NGERE, Université de Lorraine, Vandœuvre-lès-Nancy, France.", "Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, AZ, United States.", "Department of Epidemiology and Biostatistics, Western University, London, ON, Canada." ], "article_type": "research article", "arxiv": null, "author_total": 16, "authors": [ { "affs": [ 0 ], "name": "Daniel Lupas", "orcid": "0009-0006-1851-9734" }, { "affs": [ 1 ], "name": "Navneet Natt" }, { "affs": [ 0 ], "name": "Reyad Elzaanoun" }, { "affs": [ 1, 2 ], "name": "Yuhong Yuan", "orcid": "0000-0003-4374-3042" }, { "affs": [ 0, 3 ], "name": "Prince Taylor" }, { "affs": [ 2 ], "name": "Rokhsana Mortuza" }, { "affs": [ 1 ], "name": "Sudheer Vuyyuru" }, { "affs": [ 4 ], "name": "Jurij Hanzel", "orcid": "0000-0003-3158-8014" }, { "affs": [ 5, 6 ], "name": "Christopher Ma", "orcid": "0000-0002-4698-9948" }, { "affs": [ 7 ], "name": "Eileen Crowley", "orcid": "0000-0002-9545-4384" }, { "affs": [ 8 ], "name": "Neeraj Narula", "orcid": "0000-0002-1536-8436" }, { "affs": [ 9 ], "name": "Silvio Danese" }, { "affs": [ 10, 11 ], "name": "Laurent Peyrin-Biroulet", "orcid": "0000-0003-2536-6618" }, { "affs": [ 12 ], "name": "Siddharth Singh" }, { "affs": [ 1, 2, 13 ], "name": "Vipul Jairath", "orcid": "0000-0002-1092-0033" }, { "affs": [ 1, 2, 13 ], "name": "Rocio Sedano", "orcid": "0000-0002-3311-638X" } ], "bibtex": "https://research.draconitic.com/paper/b43acrre66p3b.bib", "cited_by": 0, "doi": "10.1093/ecco-jcc/jjag168", "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722441/?tool=EBI", "id": "b43acrre66p3b", "issns": [ "1873-9946", "1876-4479" ], "landing_url": "https://europepmc.org/article/PMC/PMC13722441", "language": "eng", "licence": "CC-BY", "licence_label": "CC BY", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "AcademicSubjects/MED00260" ], [ "heading", "Original Article" ], [ "openalex", "1311|Inflammatory Bowel Disease" ] ], "openalex": "W7224868219", "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722441/pdf/?tool=EBI", "pmcid": "PMC13722441", "pmid": "42963340", "published": "2026-10-01", "publisher": "Oxford University Press", "ris": "https://research.draconitic.com/paper/b43acrre66p3b.ris", "sources": [ { "first_seen": "2026-10-31T12:21:37Z", "native_id": "PMC:PMC13722441", "source": "europepmc", "url": "https://europepmc.org/article/PMC/PMC13722441" }, { "first_seen": "2026-11-02T03:21:43Z", "native_id": "MED:42963340", "source": "europepmc", "url": "https://europepmc.org/article/MED/42963340" }, { "first_seen": "2026-11-03T12:22:56Z", "native_id": "PMC13722441", "source": "pmc", "url": "https://doi.org/10.1093/ecco-jcc/jjag168" } ], "subjects": [ { "field": "biology", "origin": "openalex:1311|Inflammatory Bowel Disease", "subfield": "genetics-genomics" } ], "title": "Prevalence and epidemiologic features of adult upper gastrointestinal Crohn’s disease over the last 30 years: a scoping review", "title_text": "Prevalence and epidemiologic features of adult upper gastrointestinal Crohn’s disease over the last 30 years: a scoping review", "type": "peer-reviewed", "updated_at": "2026-11-03T12:22:56Z", "url": "https://research.draconitic.com/paper/b43acrre66p3b", "venue": "Journal of Crohn's & colitis", "versions": [] }