{
  "abstract": "End-stage kidney disease (ESKD) requires lifelong kidney replacement therapy, yet conventional hemodialysis and peritoneal dialysis remain limited by intermittent treatment, restricted mobility, and repeated dialysate exchange. Here, we developed a continuous regenerative peritoneal dialysis platform based on a nano-ring-assisted nanoelectrokinetic dialyzer for portable artificial kidney applications. We first identified key geometric and electrokinetic parameters governing the removal performance of nano-ring meshes, including mesh dimension, nano-ring coating thickness, the number of cascaded nano-rings, and the relative orientation between fluid flow and the applied electric field. We then developed a single nano-ring dialyzer operating at 1.33 mL/min and scaled the treatment capacity to approximately 10 mL min/min through parallel integration of multiple modules. In a canine model, the closed-loop system achieved approximately 10 % reduction in circulating uremic toxin levels during continuous treatment. We further improved the biocompatibility of the regenerated dialysate by integrating plate-type electrodes, activated carbon, bicarbonate buffering, and UV-C treatment. In an unanesthetized canine model, the improved system sustained continuous toxin removal for 4 h while major hepatic and inflammatory markers remained within recoverable ranges. These results demonstrate that cascaded nano-ring enables continuous dialysate regeneration with scalable throughput, reduced dependence on fresh dialysate, and in vivo control of uremic toxins, providing a technological foundation for portable or wearable regenerative peritoneal dialysis systems.",
  "abstract_shown": true,
  "affiliations": [
    "Harvard Medical School"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "W. Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "K. Kim"
    },
    {
      "name": "S. Hong"
    },
    {
      "name": "S. Lee"
    },
    {
      "name": "H. Lee"
    },
    {
      "name": "D. A. Shin"
    },
    {
      "name": "S. H. Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "K. Kim"
    },
    {
      "name": "J. Lee"
    },
    {
      "name": "K. J. Lee"
    },
    {
      "name": "W. S. Cho"
    },
    {
      "name": "H. Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "D. K. Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "H. C. Kim"
    },
    {
      "name": "M. Seo"
    },
    {
      "affs": [
        0
      ],
      "name": "D. Kim"
    },
    {
      "name": "L. P. Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Y. S. Kim"
    },
    {
      "name": "J. C. Lee"
    },
    {
      "name": "G. Y. Sung"
    },
    {
      "affs": [
        0
      ],
      "name": "S. J. Kim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b43bjdrxqvkph.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.14.751343",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.14.751343v1.full",
  "id": "b43bjdrxqvkph",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.14.751343v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioengineering"
    ],
    [
      "openalex",
      "2727|Dialysis and Renal Disease Management"
    ]
  ],
  "openalex": "W7213889547",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.14.751343v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b43bjdrxqvkph.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:33Z",
      "native_id": "10.64898/2026.09.14.751343",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.14.751343v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioengineering",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Cascaded Nano-ring Dialyzer for Continuous Regenerative Peritoneal Dialysis",
  "title_text": "Cascaded Nano-ring Dialyzer for Continuous Regenerative Peritoneal Dialysis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:23:33Z",
  "url": "https://research.draconitic.com/paper/b43bjdrxqvkph",
  "venue": "bioRxiv",
  "versions": []
}