{
  "abstract": "Small-molecule based sonosensitizers hold great promise for deep-seated tumor therapy, yet their structure–activity relationships (SARs) remained largely unexplored, hindering their further biomedical applications. Herein, we propose a counterion-engineering strategy to modulate the aggregation behaviour of aza-BODIPY dyes, thereby achieving high-performance sonodynamic therapy (SDT). We demonstrated that Cl−-paired aza-BODIPY dye (BT-Cl) formed nanoparticles with the smallest hydrodynamic diameter and yielded the highest levels of reactive oxygen species (ROS). BT-Cl NPs also displayed potent sonodynamic cytotoxicity toward both 4T1 and U87-MG cells. Consequently, BT-Cl exhibited excellent tumor growth inhibition with minimal side effects. Overall, this work underscored the critical role of noncovalent ion-pairing interactions in governing small-molecule sonosensitizer aggregation and provided a facile approach for the rational design of high-efficiency sonosensitizers.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation Huzhou 313099 China",
    "College of Chemistry, Central China Normal University Wuhan 430079 China",
    "Clinical Laboratory, Wuhan Jinyintan Hospital Wuhan 430070 China",
    "National Key Laboratory of Agricultural Microbiology, College of Biomedicine and Health, Huazhong Agricultural University Wuhan 430070 China",
    "College of Chemistry, Huazhong Agricultural University Wuhan 430070 China",
    "Hubei Jiangxia Laboratory Wuhan 430020 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "You Dou"
    },
    {
      "affs": [
        2
      ],
      "name": "Guoyan Fang"
    },
    {
      "affs": [
        1
      ],
      "name": "Junhua Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Yuting Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuntao Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Sheng Qiu"
    },
    {
      "affs": [
        4
      ],
      "name": "Jun Li",
      "orcid": "0009-0001-5075-2978"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "Yao Sun",
      "orcid": "0000-0002-6519-7436"
    },
    {
      "affs": [
        1
      ],
      "name": "Junrong Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b4503twewdcsq.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc05519b",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13549310/",
  "id": "b4503twewdcsq",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://doi.org/10.1039/d6sc05519b",
  "language": "en",
  "licence": "CC-BY-NC-3.0",
  "licence_label": "CC BY-NC 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "2204|Nanoplatforms for cancer theranostics"
    ]
  ],
  "openalex": "W7204771215",
  "pdf_url": "https://pubs.rsc.org/sc/article-pdf/doi/10.1039/D6SC05519B/13728968/d6sc05519b.pdf",
  "pmcid": "PMC13549310",
  "pmid": "42707700",
  "published": "2026-09-01",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/b4503twewdcsq.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:45Z",
      "native_id": "PMC13549310",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc05519b"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "journal-openalex:1605|Supramolecular Chemistry and Complexes",
      "subfield": "organic"
    }
  ],
  "title": "Counterion modulation of aza-BODIPY aggregation behaviour for boosted sonodynamic therapy",
  "title_text": "Counterion modulation of aza-BODIPY aggregation behaviour for boosted sonodynamic therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:52Z",
  "url": "https://research.draconitic.com/paper/b4503twewdcsq",
  "venue": "Chemical Science",
  "versions": []
}