{
  "abstract": "A series of seven pyrrolo[3,4-b]pyridin-5-ones were synthesized via a one-pot process involving an Ugi-Zhu reaction followed by a cascade sequence (N-acylation/aza Diels-Alder cycloaddition/decarboxylation/dehydration) incorporating different substituents no aromatic and aromatic such as furan, tetrahydrofuran, and pyridine. The pyrrolo[3,4-b]pyridin-5-ones were optically characterized through their photoluminescence spectra, quantum yields, and fluorescence lifetimes. By combining spectroscopic measurements with DFT/TDDFT calculations, photophysical behavior was elucidated, specifically addressing solvent effects on transition magnitudes and the electronic nature of absorption and emission states. Structure-property relationship analyses revealed that steric and electronic substituent effects govern the interplay between charge-transfer (CT) and locally excited (LE) states. Finally, the most promising candidates were successfully evaluated as fluorogenic microviscosity and polarity sensors, demonstrating their potential for advanced sensing applications.",
  "abstract_shown": true,
  "affiliations": [
    "Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, Mexico.",
    "Department of Chemistry and Biochemistry, Baylor University, Waco, Texas, USA.",
    "Departamento de Ingeniería de Procesos e Hidráulica, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, Mexico.",
    "Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, Mexico."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ivette Morales-Salazar"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlos E Garduño Albino",
      "orcid": "0009-0001-2995-4241"
    },
    {
      "affs": [
        1
      ],
      "name": "Alejandro Valderrama-Celestino"
    },
    {
      "affs": [
        2
      ],
      "name": "Federico González-García"
    },
    {
      "affs": [
        0
      ],
      "name": "Alberto Rojas",
      "orcid": "0000-0001-9716-4762"
    },
    {
      "affs": [
        0
      ],
      "name": "Annia Galano",
      "orcid": "0000-0002-1470-3060"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoarhy A Amador-Sánchez",
      "orcid": "0000-0002-5107-5358"
    },
    {
      "affs": [
        3
      ],
      "name": "Cesar A Guarin",
      "orcid": "0000-0001-7581-0137"
    },
    {
      "affs": [
        0
      ],
      "name": "Eduardo González-Zamora",
      "orcid": "0000-0002-3995-9126"
    },
    {
      "affs": [
        0
      ],
      "name": "Alejandro Islas-Jácome",
      "orcid": "0000-0003-0975-5904"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b4dsb511ehxe5.bib",
  "cited_by": 0,
  "doi": "10.1002/bio.70655",
  "fulltext_url": "https://europepmc.org/articles/PMC13686252",
  "id": "b4dsb511ehxe5",
  "issns": [
    "1522-7235",
    "1522-7243"
  ],
  "landing_url": "https://europepmc.org/article/MED/42905480",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Luminescence and Fluorescent Materials"
    ]
  ],
  "openalex": "W7223120545",
  "pdf_url": "https://europepmc.org/articles/PMC13686252?pdf=render",
  "pmcid": "PMC13686252",
  "pmid": "42905480",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b4dsb511ehxe5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42905480",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42905480"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Luminescence and Fluorescent Materials",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Tuning the Molecular Rotor Dynamics of Pyrrolo[3,4-b]Pyridin-5-Ones: Steric and Electronic Control of Environmental Sensing.",
  "title_text": "Tuning the Molecular Rotor Dynamics of Pyrrolo[3,4-b]Pyridin-5-Ones: Steric and Electronic Control of Environmental Sensing.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/b4dsb511ehxe5",
  "venue": "Luminescence : the journal of biological and chemical luminescence",
  "versions": []
}