{
  "abstract": "Renal ischemia/reperfusion injury (RI/RI) is one of the major causes of acute kidney injury (AKI). Low molecular weight-dextran sulphate (LMW-DS) is a bioactive polysaccharide with anti-inflammatory and cytoprotective properties. This study investigated the nephroprotective potential of LMW-DS against the RI/RI. RI/RI rat model underwent surgery that involved a complete bilateral clamping of renal hila for 30 min, followed by unclamping for 30 min. LMW-DS (5 mg/kg, s.c.) was injected 5 min before unclamping. After 24 h, kidneys were collected for biochemical, histopathological, and immunohistochemical examinations. RI/RI dramatically induced renal deterioration, as reflected by marked elevation in the levels of renal oxidative stress, tumor necrosis factor-α, interleukin-6, and toll-like receptor-4, indicating lipid peroxidation and inflammatory response. Furthermore, RI/RI caused upregulation of kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin. Additionally, morphological alterations and collagen deposition were also detected in kidney tissues. The immunohistochemical analysis revealed a strong positive immunoreaction for p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and caspase-3. Treatment with LMW-DS produced a pronounced amelioration in the altered parameters induced by RI/RI. In conclusion, LMW-DS exerts nephroprotective effects against RI/RI by restoring redox balance, suppressing inflammatory signaling, JNK/p38 MAPK, and caspase-3, highlighting its potential as a therapeutic strategy for renal I/R-induced AKI.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.",
    "Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.",
    "Experimental Surgery and Animal Lab, Prince Naif for Health Research Center (PNHRC), College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11451, Saudi Arabia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nadrah S Alamri"
    },
    {
      "affs": [
        0
      ],
      "name": "Ahlam M Alhusaini",
      "orcid": "0000-0003-2905-8882"
    },
    {
      "affs": [
        0
      ],
      "name": "Wedad S Sarawi",
      "orcid": "0000-0001-6376-9464"
    },
    {
      "affs": [
        0
      ],
      "name": "Hala A Attia",
      "orcid": "0000-0002-0482-5363"
    },
    {
      "affs": [
        0
      ],
      "name": "Iman H Hasan",
      "orcid": "0000-0001-7311-1412"
    },
    {
      "affs": [
        0
      ],
      "name": "Alia O Alshabanah"
    },
    {
      "affs": [
        0
      ],
      "name": "Ragad A Alharajeen"
    },
    {
      "affs": [
        0
      ],
      "name": "Ahmed A Altuwaijri"
    },
    {
      "affs": [
        0
      ],
      "name": "Faris A Almutairi"
    },
    {
      "affs": [
        1
      ],
      "name": "Hanaa M Altuwaijri"
    },
    {
      "affs": [
        0
      ],
      "name": "Dalal A Alkhelb"
    },
    {
      "affs": [
        0
      ],
      "name": "Sahar S Alotaibi",
      "orcid": "0009-0007-8690-157X"
    },
    {
      "affs": [
        2
      ],
      "name": "Abdullah Y Almubarak",
      "orcid": "0000-0003-0384-4842"
    },
    {
      "affs": [
        2
      ],
      "name": "Yasser A Alshawakir"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b4jvvp71xbte5.bib",
  "cited_by": 0,
  "doi": "10.3390/antiox15101238",
  "fulltext_url": "https://europepmc.org/articles/PMC13700585",
  "id": "b4jvvp71xbte5",
  "issns": [
    "2076-3921"
  ],
  "landing_url": "https://europepmc.org/article/MED/42939812",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Acute Kidney Injury Research"
    ]
  ],
  "openalex": "W7214398547",
  "pdf_url": "https://europepmc.org/articles/PMC13700585?pdf=render",
  "pmcid": "PMC13700585",
  "pmid": "42939812",
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b4jvvp71xbte5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42939812",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42939812"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Acute Kidney Injury Research",
      "subfield": "general"
    }
  ],
  "title": "Low Molecular Weight Dextran Sulfate Mitigates Acute Kidney Injury Induced by Renal Ischemia/Reperfusion: Implication of JNK/p38 MAPK and Caspase-3.",
  "title_text": "Low Molecular Weight Dextran Sulfate Mitigates Acute Kidney Injury Induced by Renal Ischemia/Reperfusion: Implication of JNK/p38 MAPK and Caspase-3.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/b4jvvp71xbte5",
  "venue": "Antioxidants (Basel, Switzerland)",
  "versions": []
}