{
  "abstract": "Dysregulated lipid metabolism is a core hallmark of diffuse large B-cell lymphoma (DLBCL), while the upstream non-coding RNA regulatory network targeting sphingosine kinase 1 (SPHK1), a key lipogenic kinase, remains largely uncharacterized in DLBCL. Here, we identified and validated a novel ceRNA regulatory axis consisting of circ_0006523, miR-659-3p, and SPHK1 in DLBCL clinical tissues and cell lines. circ_0006523 and SPHK1 were significantly upregulated, whereas miR-659-3p was downregulated, in DLBCL tissues and cell lines; high circ_0006523 expression was associated with advanced Ann Arbor stages (Ⅲ–IV). Mechanistically, RNase R-resistant circ_0006523 acted as a competing endogenous RNA (ceRNA) to sponge miR-659-3p, thus relieving its repression on SPHK1. Functionally, circ_0006523 promoted DLBCL cell proliferation and elevated intracellular lipid abundance via the miR-659-3p/SPHK1 axis. Collectively, the circ_0006523/miR-659-3p/SPHK1 axis modulates DLBCL proliferative phenotypes in vitro. Circ_0006523 expression correlates with advanced Ann Arbor stage in a limited DLBCL cohort, and this axis may provide preliminary molecular insights for further investigation in DLBCL.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Qixiang Zhou"
    },
    {
      "name": "Yubo Yang"
    },
    {
      "name": "Xingyan Guo"
    },
    {
      "name": "Cuijuan Qian",
      "orcid": "0009-0008-3469-9063"
    },
    {
      "name": "Jun Yao",
      "orcid": "0000-0002-1088-1548"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b4qppyp81ngv9.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-73888-8",
  "fulltext_url": null,
  "id": "b4qppyp81ngv9",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-73888-8",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Circular RNAs in diseases"
    ]
  ],
  "openalex": "W7220867627",
  "pdf_url": "https://www.nature.com/articles/s41598-026-73888-8_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/b4qppyp81ngv9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1038/s41598-026-73888-8",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-73888-8"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Circular RNAs in diseases",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Circular RNA circ_0006523 promotes lipid accumulation and proliferation of diffuse large B-cell lymphoma via the miR-659-3p/SPHK1 axis",
  "title_text": "Circular RNA circ_0006523 promotes lipid accumulation and proliferation of diffuse large B-cell lymphoma via the miR-659-3p/SPHK1 axis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/b4qppyp81ngv9",
  "venue": "Scientific Reports",
  "versions": []
}