{
  "abstract": "Background: Ascorbic acid, a crucial antioxidant, is transported from blood to cerebrospinal fluid (CSF) via the choroid plexus (ChP). A noninvasive tool to visualize and quantify ascorbic acid transport process in the human brain is currently lacking. We aimed to determine whether 6-deoxy-6-[18F]fluoro-L-ascorbic acid ([18F]FAA) PET can visualize and quantify ascorbic acid transport from blood to CSF via the ChP in humans.\n\nMethods: This prospective secondary analysis evaluated participants between May 2024 and September 2024. Eight participants underwent a 45-minute dynamic brain [18F]FAA PET/CT scan; 153 participants underwent a static [18F]FAA PET/CT scan. Tracer accumulation in ChP and CSF were measured in the lateral and fourth ventricles. Univariable and multivariable linear regression models were used to investigate the associated factors of [18F]FAA PET metrics.\n\nResults: One hundred sixty-one participants (mean age, 48.0 years ± 15.7 [SD]; 90 women) were evaluated. Dynamic [18F]FAA PET showed rapid ChP tracer accumulation in the lateral and fourth ventricles, peaking at about 5 min post-injection followed by declining, while CSF [18F]FAA standardized uptake value progressively increased. The area under the curve of the time-activity curves from 0 to 40 min was significantly higher in the young group (<60 years, n = 4) than in the elderly group (≥ 60 years, n = 4) in the ChP. Multiple linear regression analyses showed age was independently and negatively associated with [18F]FAA accumulation in the ChP and CSF.\n\nConclusions: [18F]FAA PET is a non-invasive tool for visualizing and assessing choroid plexus ascorbic acid transport in humans.\n\nClinical trial number: (ChiCTR2300076126: http://www.chictr.org.cn/) with the Clinical Trial Registry (2023-09-25).\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12987-026-00847-w.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, Guangdong Province 510080 China",
    "Department of Nuclear Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, Guangdong Province 518107 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuying Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaofeng Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Haoyue Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yali Long"
    },
    {
      "affs": [
        0
      ],
      "name": "Tianhong Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Kunyuan Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Songhan Ge"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiao He"
    },
    {
      "affs": [
        0
      ],
      "name": "Bing Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Ningyi Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhihao Zha"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiangsong Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b4vffgkkzh2mc.bib",
  "cited_by": 0,
  "doi": "10.1186/s12987-026-00847-w",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13711760/",
  "id": "b4vffgkkzh2mc",
  "issns": [
    "2045-8118"
  ],
  "landing_url": "https://doi.org/10.1186/s12987-026-00847-w",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2804|Cerebrospinal fluid and hydrocephalus"
    ]
  ],
  "openalex": "W7171548002",
  "pdf_url": null,
  "pmcid": "PMC13711760",
  "pmid": "42934786",
  "published": "2026-07-28",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/b4vffgkkzh2mc.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:29Z",
      "native_id": "PMC13711760",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12987-026-00847-w"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Cerebrospinal fluid and hydrocephalus",
      "subfield": "neuroscience"
    }
  ],
  "title": "Ascorbic acid transport via choroid plexus measured with 6-deoxy-6-[18F]fluoro-L-ascorbic acid PET",
  "title_text": "Ascorbic acid transport via choroid plexus measured with 6-deoxy-6-[18F]fluoro-L-ascorbic acid PET",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:29Z",
  "url": "https://research.draconitic.com/paper/b4vffgkkzh2mc",
  "venue": "Fluids and Barriers of the CNS",
  "versions": []
}