{
  "abstract": "To characterize the diagnostic performance of susceptibility-weighted imaging (SWI), χ-separation-derived paramagnetic susceptibility (χpara), and apparent diffusion coefficient (ADC) for differentiating multiple system atrophy-Parkinsonian type (MSA-P) from Parkinson's disease (PD). This retrospective case-control study included 27 drug-naïve patients with MSA-P and 27 age- and sex-matched drug-naïve patients with PD. Clinical diagnosis by board-certified neurologists served as the reference standard. χpara maps were generated from multi-echo gradient-recalled echo images using χ-separation, and ADC maps were derived from diffusion-weighted imaging. Two blinded radiologists qualitatively assessed SWI and ADC images using prespecified putaminal criteria. Quantitative analyses included voxel-wise group comparison and receiver operating characteristic (ROC) analysis using mean region-of-interest (ROI) values. Candidate logistic-regression models were assessed using leave-one-out cross-validation. Qualitative assessment yielded sensitivity (85.2%), specificity (100%) and accuracy (92.6%) for SWI; the corresponding ADC assessments were 70.4%, 77.8% and 74.1%, respectively. Voxel-wise χpara analysis revealed a rim-shaped susceptibility increase in the posterior putamen, whereas ADC differences were localized to cerebellar white matter, including the middle cerebellar peduncle (MCP). In ROI-based classification, putaminal χpara yielded a sensitivity of 92.6% and ADC of the MCP showed a specificity of 96.3%. An exploratory model combining putaminal χpara and ADC in the MCP yielded a leave-one-out cross-validation AUC of 0.927. By evaluating susceptibility-based imaging and ADC in the same cohort, this study characterized their respective regional imaging features and diagnostic performance for differentiating MSA-P from PD. χpara revealed an observed rim-shaped susceptibility pattern in the posterior putamen, supporting further evaluation of this pattern as a candidate imaging finding in MSA-P.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.",
    "Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.",
    "Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Byeongpil Moon"
    },
    {
      "affs": [
        1
      ],
      "name": "So Yeon Won"
    },
    {
      "affs": [
        0
      ],
      "name": "Jonghyo Youn"
    },
    {
      "affs": [
        1
      ],
      "name": "Yujin Seo"
    },
    {
      "affs": [
        2
      ],
      "name": "Jinyoung Youn"
    },
    {
      "affs": [
        1
      ],
      "name": "Eung Yeop Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Jongho Lee"
    },
    {
      "affs": [
        1
      ],
      "name": "Beomseok Sohn"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b58918q76swhg.bib",
  "cited_by": 0,
  "doi": "10.3389/fnagi.2026.1967702",
  "fulltext_url": "https://europepmc.org/articles/PMC13713838",
  "id": "b58918q76swhg",
  "issns": [
    "1663-4365"
  ],
  "landing_url": "https://europepmc.org/article/MED/42952865",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2741|Advanced MRI Techniques and Applications"
    ]
  ],
  "openalex": "W7221815534",
  "pdf_url": "https://europepmc.org/articles/PMC13713838?pdf=render",
  "pmcid": "PMC13713838",
  "pmid": "42952865",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/b58918q76swhg.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42952865",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952865"
    },
    {
      "first_seen": "2026-11-01T12:21:26Z",
      "native_id": "PMC13713838",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fnagi.2026.1967702"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Advanced MRI Techniques and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "Diagnostic value of susceptibility-based imaging and apparent diffusion coefficient for differentiating multiple system atrophy-Parkinsonian type from Parkinson's disease.",
  "title_text": "Diagnostic value of susceptibility-based imaging and apparent diffusion coefficient for differentiating multiple system atrophy-Parkinsonian type from Parkinson's disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:26Z",
  "url": "https://research.draconitic.com/paper/b58918q76swhg",
  "venue": "Frontiers in aging neuroscience",
  "versions": []
}