{
  "abstract": "Preoperative prediction of lymph node metastasis (LNM) in extrahepatic cholangiocarcinoma (ECC) is crucial for surgical strategies and prognosis, as current imaging methods are insufficient. A total of 149 ECC patients who underwent curative resection were retrospectively analyzed. We measured the Coefficient of Variation (CV) of CT values, ADC of MRI, and SUVmax of PET/CT from multiple lymph nodes. Diagnostic performance for LNM prediction was evaluated using ROC curve analysis. The CV of CT values was the most powerful independent predictor of LNM. Its AUC (0.829) was superior to MRI ADC (0.666) and PET/CT SUVmax (0.701). The CV of CT values showed a sensitivity of 72.8%, specificity of 72.9%, and accuracy of 72.9%. In conclusion, The CV of CT values is a promising and effective parameter for preoperatively predicting LNM in ECC. This can potentially improve patient selection for neoadjuvant therapies and surgical planning.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan",
    "Department of Surgery, Keio University School of Medicine, Tokyo, Japan"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Naokazu Chiba"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuta Abe"
    },
    {
      "name": "Hirotaka Kojima"
    },
    {
      "name": "Ryota Suda"
    },
    {
      "name": "Masashi Nakagawa"
    },
    {
      "name": "Shigeto Ochiai"
    },
    {
      "name": "Takahiro Gunji"
    },
    {
      "name": "Toru Sano"
    },
    {
      "name": "Satoshi Tabuchi"
    },
    {
      "name": "Tetsuo Ishizaki"
    },
    {
      "name": "Shigeyuki Kawachi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b595beb52ad0q.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0357578",
  "fulltext_url": null,
  "id": "b595beb52ad0q",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0357578",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Cholangiocarcinoma and Gallbladder Cancer Studies"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Lymphatic system/Lymph nodes"
    ],
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Neuroimaging/Computed axial tomography"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Lymphatic system/Lymph nodes"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Clinical oncology/Surgical oncology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Diagnostic radiology/Magnetic resonance imaging"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Diagnostic radiology/Tomography/Computed axial tomography"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Basic cancer research/Metastasis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment/Surgical oncology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Carcinoma/Adenocarcinoma/Cholangiocarcinoma"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Gastrointestinal tumors/Cholangiocarcinoma"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Lung and intrathoracic tumors/Non-small cell lung cancer"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Clinical oncology/Surgical oncology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Metastasis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Radiology and imaging/Diagnostic radiology/Magnetic resonance imaging"
    ],
    [
      "plos",
      "/Medicine and health sciences/Radiology and imaging/Diagnostic radiology/Tomography/Computed axial tomography"
    ],
    [
      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Diagnostic radiology/Magnetic resonance imaging"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Diagnostic radiology/Tomography/Computed axial tomography"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Neuroimaging/Computed axial tomography"
    ]
  ],
  "openalex": "W7212320867",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357578&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/b595beb52ad0q.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "10.1371/journal.pone.0357578",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0357578"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:diagnostic radiology",
      "subfield": "imaging"
    },
    {
      "field": "medicine",
      "origin": "plos:oncology",
      "subfield": "oncology"
    }
  ],
  "title": "The coefficient of variation of CT values for predicting lymph node metastasis in extrahepatic cholangiocarcinoma",
  "title_text": "The coefficient of variation of CT values for predicting lymph node metastasis in extrahepatic cholangiocarcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/b595beb52ad0q",
  "venue": "PLOS One",
  "versions": []
}