{
  "abstract": "Citrus hystrix, a member of the genus Citrus, is a widely recognized plant in VIET NAM with diverse applications in herbal medicine, gastronomy, and cosmetics. However, the anti-inflammatory effect of the essential oil extracted from C. hystrix leaves has not been investigated yet. GC/MS analysis identified 40 chemical constituents in the leaf essential oil (EOL) from C. hystrix, accounting for 97.42 % of the total peak area. The predominant compounds included citronellol (22.28 %), citronellal (17.75 %), linalool (9.53 %), and nerolidol (8.69 %). Molecular docking studies revealed strong binding affinities between these compounds and two key inflammatory mediators, cyclooxygenase-2 and inducible nitric oxide synthase, with binding energies ranging from -5.4 to -7.2 kcal/mol. These findings suggest a moderate anti-inflammatory potential of the EOL. This was further supported by an in vitro cell-based approach, in which EOL demonstrated a moderate inhibitory effect on nitric oxide production at a concentration of 20 μg/mL, resulting in a reduction of 26.79 ± 1.77 %. Furthermore, EOL weakly inhibited heat-induced protein denaturation with an IC50 value of approximately 311.40 ± 30.04 μg/mL. To the best of our knowledge, this is the first report to investigate the anti-inflammatory activity of C. hystrix leaf essential oil, providing a foundation for future research into its therapeutic applications for managing inflammatory conditions.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Gia-Buu Tran"
    },
    {
      "name": "Tuong-Vy Thi Le"
    },
    {
      "name": "Hoang Phu Nguyen"
    },
    {
      "name": "Mong Kha Tran"
    },
    {
      "name": "Khanh-Linh Chung"
    },
    {
      "name": "Huy Vu Nguyen"
    },
    {
      "name": "Bich Hang Do"
    },
    {
      "name": "Huy Truong Nguyen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b5jbka976ddg3.bib",
  "cited_by": 0,
  "doi": "10.5650/jos.ess26025",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/jos/75/9/75_jos.ess26025/_article",
  "id": "b5jbka976ddg3",
  "issns": [
    "1347-3352",
    "1345-8957"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/jos/75/9/75_jos.ess26025/_article",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "chemistry/general"
    ],
    [
      "openalex",
      "1106|Essential Oils and Antimicrobial Activity"
    ]
  ],
  "openalex": "W7204747785",
  "pdf_url": "https://www.jstage.jst.go.jp/article/jos/75/9/75_jos.ess26025/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b5jbka976ddg3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.5650/jos.ess26025",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/jos/75/9/75_jos.ess26025/_article"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "jstage-journal:chemistry/general",
      "subfield": "general"
    }
  ],
  "title": "Molecular docking and anti-inflammatory effect of the essential oil isolated from Chuc leaf (Citrus hystrix) cultivated in VIET NAM",
  "title_text": "Molecular docking and anti-inflammatory effect of the essential oil isolated from Chuc leaf (Citrus hystrix) cultivated in VIET NAM",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/b5jbka976ddg3",
  "venue": "Journal of Oleo Science",
  "versions": []
}