{
  "abstract": "Even though osteoarthritis is considered a disease of the whole joint, integrated analysis of articular calcified cartilage (ACC) behaviour with adjacent tissues remains a persistent limitation. Herein, we performed synchrotron X-ray computed tomography in intact loaded joints and coupled anatomical analysis with digital volume correlation to examine whether microarchitectural ACC features serve as predictive mechano-biomarkers of osteoarthritis. We reveal that male osteoarthritis-prone STR/Ort mice have thicker yet more porous ACC that contains larger but less spherical chondrocyte lacunae than their healthy parental-control CBA mice. This was linked to asymmetrical distribution of tensile and compressive strains generated under physiological loads in the ACC and underlying subchondral bone in tibial epiphyses of STR/Ort mice. Together these data suggest that murine ACC microarchitecture has a mechano-predictive role in age-related osteoarthritis.",
  "abstract_shown": true,
  "affiliations": [
    "University of Brighton"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "L. A. Evans"
    },
    {
      "name": "A. Sharma"
    },
    {
      "name": "J. Chen"
    },
    {
      "name": "L. E. Bourne"
    },
    {
      "name": "A. L. Parmenter"
    },
    {
      "name": "J. Brunet"
    },
    {
      "name": "K. Madi"
    },
    {
      "name": "S. Marussi"
    },
    {
      "name": "P. D. Lee"
    },
    {
      "name": "A. A. Pitsillides"
    },
    {
      "affs": [
        0
      ],
      "name": "K. A. Staines"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b5mkm79ks4n19.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.18.752585",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752585v1.full",
  "id": "b5mkm79ks4n19",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752585v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "physiology"
    ],
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
    ]
  ],
  "openalex": "W7214149918",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752585v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b5mkm79ks4n19.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:27Z",
      "native_id": "10.64898/2026.09.18.752585",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.18.752585v2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:physiology",
      "subfield": "physiology"
    }
  ],
  "title": "Articular calcified cartilage microarchitecture has a predictive role in abnormal osteochondral strain distributions in murine age-related osteoarthritis",
  "title_text": "Articular calcified cartilage microarchitecture has a predictive role in abnormal osteochondral strain distributions in murine age-related osteoarthritis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:33Z",
  "url": "https://research.draconitic.com/paper/b5mkm79ks4n19",
  "venue": "bioRxiv",
  "versions": []
}