{
  "abstract": "Late-onset psychosis (LOP) exhibits distinct clinical features compared with younger-onset psychosis. Although postmortem and epidemiological studies have suggested an association between LOP and neurodegenerative processes, particularly tauopathies, in vivo evidence remains limited. This study aimed to investigate the involvement of Alzheimer’s disease (AD) and non-AD tauopathies in LOP using amyloid PET and tau PET with florzolotau (18F) (18F-florzolotau; also known as 18F-APN-1607 or 18F-PM-PBB3), a tracer capable of detecting a broad range of tau pathologies. Thirty-seven patients with LOP and 47 age-matched controls underwent PET scans with 11C-PiB and 18F-florzolotau to assess group differences in amyloid beta (Aβ) and tau accumulation. Diagnostic effects on regional 18F-florzolotau standardized uptake value ratios (SUVRs) were assessed. Associations between regional SUVRs and cognitive and clinical features were examined separately in Aβ-positive and Aβ-negative subgroups. Patients exhibited significantly higher positivity rates for both Aβ (13 of 37 patients, 35.1%) and tau (24 patients, 64.9%) than controls (one of 47 controls, 2.1% for Aβ and seven controls, 14.9% for tau). A significant diagnostic effect was observed on regional 18F-florzolotau SUVRs (P = 0.004), with post-hoc analyses revealing increased tracer retention in the parietal cortex. This diagnostic effect remained robust when the analysis was restricted to Aβ-negative participants (P = 0.002). Among Aβ-positive patients, greater parietal tau burden was associated with lower Frontal Assessment Battery scores. In conclusion, this in vivo PET study demonstrated a high prevalence of AD-like and non-AD-like tau accumulation patterns in LOP, suggesting that LOP may be associated with heterogeneous tau-related neurodegenerative processes.",
  "abstract_shown": true,
  "affiliations": [
    "Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba 263-8555 Japan",
    "Department of Psychiatry, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Kyoto 606-8507 Japan",
    "Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 Japan",
    "Department of Psychiatry, Jikei University Graduate School of Medicine, 3-19-18 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461 Japan",
    "Department of Psychiatry and Behavioral Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519 Japan",
    "Department of Psychiatry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Nara 634-8522 Japan",
    "Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Center, 578 Hetacho, Midori-ku, Chiba, Chiba 266-0007 Japan",
    "Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba 263-8555 Japan",
    "Neuroetiology and Diagnostic Science, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Osaka 545-8585 Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Manabu Kubota",
      "orcid": "0000-0001-9507-1845"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Shin Kurose",
      "orcid": "0000-0001-8355-4946"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Kenji Tagai"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuki Momota"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Masanori Ichihashi",
      "orcid": "0009-0001-0431-4125"
    },
    {
      "affs": [
        0
      ],
      "name": "Hironobu Endo"
    },
    {
      "affs": [
        0
      ],
      "name": "Chie Seki"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Sho Moriguchi"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yasuharu Yamamoto",
      "orcid": "0000-0002-1954-8004"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuko Kataoka"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryoji Goto",
      "orcid": "0000-0002-1693-9915"
    },
    {
      "affs": [
        4
      ],
      "name": "Takehiro Tamura"
    },
    {
      "affs": [
        4
      ],
      "name": "Hiroki Shiwaku"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Kiwamu Matsuoka"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Hisaomi Suzuki"
    },
    {
      "affs": [
        6
      ],
      "name": "Mitsumoto Onaya"
    },
    {
      "affs": [
        0
      ],
      "name": "Takahiko Tokuda"
    },
    {
      "affs": [
        2
      ],
      "name": "Hiroyuki Uchida",
      "orcid": "0000-0002-0628-7036"
    },
    {
      "affs": [
        4
      ],
      "name": "Hidehiko Takahashi"
    },
    {
      "affs": [
        7
      ],
      "name": "Kazunori Kawamura",
      "orcid": "0000-0001-6786-678X"
    },
    {
      "affs": [
        7
      ],
      "name": "Ming-Rong Zhang"
    },
    {
      "affs": [
        0,
        8
      ],
      "name": "Makoto Higuchi"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Keisuke Takahata",
      "orcid": "0000-0002-0884-4924"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b5rpj6ch0y6gd.bib",
  "cited_by": 0,
  "doi": "10.1038/s41380-026-03749-3",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736494/",
  "id": "b5rpj6ch0y6gd",
  "issns": [
    "1359-4184",
    "1476-5578"
  ],
  "landing_url": "https://doi.org/10.1038/s41380-026-03749-3",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7172310284",
  "pdf_url": "https://www.nature.com/articles/s41380-026-03749-3.pdf",
  "pmcid": "PMC13736494",
  "pmid": "42547799",
  "published": "2026-08-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b5rpj6ch0y6gd.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:55Z",
      "native_id": "PMC13736494",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41380-026-03749-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "High prevalence of tau pathologies in late-onset psychosis: A PET study",
  "title_text": "High prevalence of tau pathologies in late-onset psychosis: A PET study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:55Z",
  "url": "https://research.draconitic.com/paper/b5rpj6ch0y6gd",
  "venue": "Molecular Psychiatry",
  "versions": []
}