{
  "abstract": "Ferroptosis resistance contributes to pathological skin scarring, but the underlying regulatory mechanisms remain unclear. Here, we identified a novel selective autophagy pathway NEURL1-SQSTM1/p62-SLC40A1 that controls fibroblast ferroptosis and scar formation. SLC40A1 is upregulated in human scars, conferring ferroptosis resistance by promoting iron efflux. Mechanistically, NEURL1 mediates K63-linked ubiquitination of SLC40A1, enabling its recognition by SQSTM1 for lysosomal degradation. A microneedle system co-delivering curcumin (autophagy activator) and siSLC40A1 effectively activates this axis, induces ferroptosis, and alleviates scarring in vivo. Our findings reveal a new therapeutic target and strategy for pathological scars.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, China.",
    "Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.",
    "Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.",
    "Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, China. Electronic address: lawrence_m@outlook.com.",
    "Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China. Electronic address: liusy@sj-hospital.org."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mengzhu Lv"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiamei Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qi Dong"
    },
    {
      "affs": [
        2
      ],
      "name": "Zibo Guo"
    },
    {
      "affs": [
        2
      ],
      "name": "Qianlong Wu"
    },
    {
      "affs": [
        3
      ],
      "name": "Simeng Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Shengye Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b5s2n12z78qtc.bib",
  "cited_by": 0,
  "doi": "10.1016/j.redox.2026.104420",
  "fulltext_url": "https://europepmc.org/articles/PMC13678046",
  "id": "b5s2n12z78qtc",
  "issns": [
    "2213-2317"
  ],
  "landing_url": "https://europepmc.org/article/MED/42858534",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Ferroptosis and cancer prognosis"
    ]
  ],
  "openalex": "W7214807641",
  "pdf_url": "https://europepmc.org/articles/PMC13678046?pdf=render",
  "pmcid": "PMC13678046",
  "pmid": "42858534",
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b5s2n12z78qtc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42858534",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42858534"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "journal-openalex:1312|Redox biology and oxidative stress",
      "subfield": "molecular-biology"
    }
  ],
  "title": "NEURL1-mediated K63-ubiquitination of SLC40A1 drives ferroptosis resistance in pathological scars: Therapeutic targeting via autophagy-activating microneedles.",
  "title_text": "NEURL1-mediated K63-ubiquitination of SLC40A1 drives ferroptosis resistance in pathological scars: Therapeutic targeting via autophagy-activating microneedles.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/b5s2n12z78qtc",
  "venue": "Redox biology",
  "versions": []
}