{
  "abstract": "The photoredox/pyridine N-oxide-catalyzed acyl radical addition of aldehydes to alkynes was developed for the divergent synthesis of pyrroles, cyclopentanones, and indanones. Acyl radicals are generated directly from aldehydes through pyridine N-oxy radical-mediated hydrogen-atom transfer under blue LED light irradiation. A series of densely functionalized pyrroles were synthesized from primary aliphatic aldehydes, acetylenedicarboxylates, and amines through sequential acyl radical addition and Paal-Knorr condensation. By changing the aldehyde component, branched aldehydes afforded substituted cyclopentanones through a radical formal [3 + 2] cyclization, whereas aryl aldehydes revealed an additional indanone-forming pathway. Radical trapping, fluorescence quenching, and electrochemical studies support photoredox oxidation of pyridine N-oxide to the active N-oxy radical, followed by aldehydic C-H abstraction as the key step for acyl radical generation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry & Chemical Biology, Indiana University Indianapolis, Indianapolis, Indiana, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Saranya Vadakke Poikayil Sasi"
    },
    {
      "affs": [
        0
      ],
      "name": "Lindsey Soruco"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongming Deng",
      "orcid": "0000-0002-9728-1325"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b5xc14z9pe03e.bib",
  "cited_by": 0,
  "doi": "10.1002/adsc.70748",
  "fulltext_url": "https://europepmc.org/articles/PMC13671234",
  "id": "b5xc14z9pe03e",
  "issns": [
    "1615-4150",
    "1615-4169"
  ],
  "landing_url": "https://europepmc.org/article/MED/42890266",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7212060999",
  "pdf_url": "https://europepmc.org/articles/PMC13671234?pdf=render",
  "pmcid": "PMC13671234",
  "pmid": "42890266",
  "published": "2026-09-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b5xc14z9pe03e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:18Z",
      "native_id": "MED:42890266",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42890266"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Photoredox/Pyridine N-Oxide Catalyzed Acyl Radical Generation From Aldehydes for Divergent Synthesis of Pyrroles and Carbocyclic Ketones.",
  "title_text": "Photoredox/Pyridine N-Oxide Catalyzed Acyl Radical Generation From Aldehydes for Divergent Synthesis of Pyrroles and Carbocyclic Ketones.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:18Z",
  "url": "https://research.draconitic.com/paper/b5xc14z9pe03e",
  "venue": "Advanced synthesis & catalysis",
  "versions": []
}