{
  "abstract": "The incretin hormone glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) are central regulators of glucose-stimulated insulin secretion and major targets in type 2 diabetes. 6-Gingerol, the principal bioactive constituent of ginger, has a reported insulinotropic action that depends on GLP-1 in vivo, but whether this reflects GLP-1 secretion from intestinal L-cells or signaling at the β-cell GLP-1R is unresolved. Using NCI-H716 and STC-1 L-cells and MIN6 β-cells, we examined whether 6-Gingerol acts as a GLP-1 secretagogue or at the β-cell. 6-Gingerol did not stimulate GLP-1 secretion. It had no effect in NCI-H716 cells and reduced secretion in STC-1 cells at concentrations that did not reduce viability. In MIN6 β-cells, 6-Gingerol potentiated insulin secretion in a bell-shaped manner. This effect was abolished by two mechanistically distinct GLP-1R antagonists and by protein kinase A inhibition and was accompanied by a GLP-1R-dependent rise in cAMP. MIN6 cells expressed Glp1r transcript, and Exendin-4 confirmed a functional receptor response. These findings suggest that 6-Gingerol acts at the β-cell through GLP-1R-, cAMP-, and PKA-dependent mechanisms and not as an L-cell GLP-1 secretagogue. At the pharmacological concentration used, these results suggest an in vitro mechanism rather than a physiological dietary effect, and in vivo validation is needed.",
  "abstract_shown": true,
  "affiliations": [
    "Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan 10540, Thailand"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Vilasinee Intisang"
    },
    {
      "affs": [
        0
      ],
      "name": "Piyathida Yameephai"
    },
    {
      "affs": [
        0
      ],
      "name": "Kwanchanok Uppakara",
      "orcid": "0009-0004-1478-1976"
    },
    {
      "affs": [
        0
      ],
      "name": "Nutthapoom Pathomthongtaweechai",
      "orcid": "0009-0008-1759-9845"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b6d2azemnnkm6.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209114",
  "fulltext_url": "https://europepmc.org/articles/PMC13704961",
  "id": "b6d2azemnnkm6",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9114",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Pancreatic function and diabetes"
    ]
  ],
  "openalex": "W7221789861",
  "pdf_url": "https://europepmc.org/articles/PMC13704961?pdf=render",
  "pmcid": "PMC13704961",
  "pmid": "42941884",
  "published": "2026-10-14",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/b6d2azemnnkm6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27209114",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9114"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42941884",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42941884"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Pancreatic function and diabetes",
      "subfield": "surgery"
    }
  ],
  "title": "6-Gingerol Potentiates β-Cell Insulin Secretion Without Acting as an L-Cell GLP-1 Secretagogue",
  "title_text": "6-Gingerol Potentiates β-Cell Insulin Secretion Without Acting as an L-Cell GLP-1 Secretagogue",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/b6d2azemnnkm6",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}