{
  "abstract": "BACKGROUND: Takayasu arteritis (TA) is a chronic large-vessel vasculitis with significant age-related heterogeneity. Global data highlight differences between adult and pediatric TA, as well as among different pediatric age groups. However, the epidemiology and clinical features of childhood-onset TA in the Russian population are largely unknown.\n\nAIM: To characterize the clinical and laboratory features, age-related differences, and long-term outcomes of TA in a Russian pediatric cohort.\n\nMETHODS: A retrospective multicenter cohort study included 79 patients aged under 18 years with TA, diagnosed according to EULAR/PRINTO/PRES criteria, from four centers in the Russian Federation. Demographic, clinical, laboratory, and instrumental data were collected. Patients were stratified into two age groups according to WHO definitions: Children (aged less than 10 years, n = 25) and adolescents (aged 10 years to 17 years inclusive, n = 54). Disease activity was assessed using ITAS2010 and ITAS.A. Statistical analysis was performed using StatTech v.4.12.2.\n\nRESULTS: The median age at onset was 11.0 (8.0-14.0) years, and the time before diagnosis was 8.0 (2.0-17.5) months; females were 78.5%. The most common clinical manifestations were malaise (84.8%), fever (54.4%), and vascular bruits (54.4%). Children under 10 years had a lower proportion of girls (P = 0.016), lower erythrocyte sedimentation rate, C-reactive protein, and platelet levels (P < 0.05), ITAS.A scores (8.9 ± 4.3 vs 12.0 ± 4.4, P = 0.005), required more surgical interventions at diagnosis (32% vs 7.4%, P = 0.008) compared to adolescents. At follow-up, 34.4% of patients had persistent vascular imaging activity despite normalized laboratory parameters. Biological drugs were used in 50.6% of patients. Three patients died, all due to postoperative complications.\n\nCONCLUSION: This pioneer Russian cohort study of childhood-onset TA reveals a unique clinical phenotype. Younger children show lower levels of inflammation than adolescents, yet they still require more surgical intervention.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Vera A Podzolkova"
    },
    {
      "name": "Natalia A Geppe"
    },
    {
      "name": "Anastasia A Glazyrina"
    },
    {
      "name": "Sania I Valieva"
    },
    {
      "name": "Ilia S Avrusin"
    },
    {
      "name": "Seda Kh Kurbanova"
    },
    {
      "name": "Svetlana S Vakhlyarskaya"
    },
    {
      "name": "Yulia O Kostina"
    },
    {
      "name": "Valeria T Yudina"
    },
    {
      "name": "Ekaterina A Lagutina"
    },
    {
      "name": "Maria K Osminina"
    },
    {
      "name": "Elena S Zholobova"
    },
    {
      "name": "Nadezhda S Podchernyaeva"
    },
    {
      "name": "Eva P Turginekova"
    },
    {
      "name": "Lyubov S Sorokina"
    },
    {
      "name": "Siuzanna A Davtian"
    },
    {
      "name": "Mikhail M Kostik"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b6e1xpc9rd594.bib",
  "cited_by": 0,
  "doi": "10.5409/wjcp.120832",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720589/",
  "id": "b6e1xpc9rd594",
  "issns": [
    "2219-2808"
  ],
  "landing_url": "https://doi.org/10.5409/wjcp.120832",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Retrospective Cohort Study"
    ],
    [
      "openalex",
      "2740|Vasculitis and related conditions"
    ]
  ],
  "openalex": "W7163178765",
  "pdf_url": null,
  "pmcid": "PMC13720589",
  "pmid": "42964757",
  "published": "2026-11-03",
  "publisher": "Baishideng Publishing Group Inc",
  "ris": "https://research.draconitic.com/paper/b6e1xpc9rd594.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:26Z",
      "native_id": "PMC13720589",
      "source": "pmc",
      "url": "https://doi.org/10.5409/wjcp.120832"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Vasculitis and related conditions",
      "subfield": "general"
    }
  ],
  "title": "Does Takayasu arteritis differ between children and adolescents? Insights from a Russian multicenter cohort",
  "title_text": "Does Takayasu arteritis differ between children and adolescents? Insights from a Russian multicenter cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:26Z",
  "url": "https://research.draconitic.com/paper/b6e1xpc9rd594",
  "venue": "World Journal of Clinical Pediatrics",
  "versions": []
}