{
  "abstract": "Cubosome based lipid nanoparticles have emerged as a premier system for drug loading and delivery. Their outstanding preclinical results underscore the importance of precision medicine for developing next generation nanomedicines. We have reported a novel engineered route for insitu formation and hybridization of cubosome based nanomaterial (lipid-g-C₃N₄-cisplatin nanoparticle), integrated with polymeric carbon nitride and cisplatin. Using an interfacial aqueous organic phase drive, we have successfully achieved cubic architecture with particle diameters of 150-200 nm. Cryogenic electron microscopy confirmed about structural integrity, while zeta potential measurements indicated to the stability with a near positive surface charge. Electron paramagnetic resonance spin trapping experiments demonstrated to the capacity of generating reactive oxygen species, specifically peroxide and superoxide. C57BL/6 mice intravenously injected with the nanoparticle which have shown preferential biodistribution in the lungs (0.09 ug Pt/g), liver (0.03 ug Pt/g), kidneys (0.06 ug Pt/g), and plasma (0.012 ug Pt/ml). The nanoparticle accumulation have exhibited a minimum in the thymus, heart, spleen, and intestines. Under dark conditions, IC₅₀ was 176.2 µg/mL for A549 cells, 139.1 µg/mL for Tong cells, and 279.3 µg/mL for HEK-293T cells. The efficacy of photodynamic therapy observed at concentrations of 50-200 µg/mL for A549 cells and 100-200 µg/mL for Tong and HEK-293T cells, highlighting that the efficiency of nanoplatform towards oncological applications in the organs of lungs, liver, and kidneys.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Research, Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, 40403, Taiwan.",
    "Department of Obstetrics and Gynecology, Asia University Hospital, Taichung, 41354, Taiwan.",
    "Graduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung, 40403, Taiwan.",
    "Instrument Center, Office of Research and Development, National Chung Hsing University, Taichung, 402227, Taiwan.",
    "Institute of Chemistry, Academia Sinica, Taipei, 115201, Taiwan.",
    "Department of Chemistry, National Chung Hsing University, Taichung, 402227, Taiwan.",
    "Department of Chemistry, Lady Brabourne College, Kolkata, 700017, India.",
    "Department of Obstetrics and Gynecology, Asia University Hospital, Taichung, 41354, Taiwan. 052471@tool.caaumed.org.tw.",
    "Department of Medical Research, Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, 40403, Taiwan. maverick@mail.cmu.edu.tw.",
    "Graduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung, 40403, Taiwan. maverick@mail.cmu.edu.tw.",
    "Office of Research and Development, Asia University, Taichung, 41354, Taiwan. maverick@mail.cmu.edu.tw."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Sk Jahir Abbas",
      "orcid": "0000-0003-2061-9639"
    },
    {
      "affs": [
        2
      ],
      "name": "Shiraz Mehmood"
    },
    {
      "affs": [
        3
      ],
      "name": "Yen-Hsien Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Sabina Yesmin"
    },
    {
      "affs": [
        5
      ],
      "name": "Cheng-Kuan Su"
    },
    {
      "affs": [
        6
      ],
      "name": "Nayim Sepay"
    },
    {
      "affs": [
        2
      ],
      "name": "Chih-Sheng Chiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei-Chun Chang"
    },
    {
      "affs": [
        7
      ],
      "name": "Yao-Ching Hung"
    },
    {
      "affs": [
        8,
        9,
        10
      ],
      "name": "Wen-Lung Ma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b6hy0cytajxqp.bib",
  "cited_by": 0,
  "doi": "10.1186/s11671-026-05076-6",
  "fulltext_url": "https://europepmc.org/articles/PMC13719956",
  "id": "b6hy0cytajxqp",
  "issns": [
    "2731-9229"
  ],
  "landing_url": "https://europepmc.org/article/MED/42955194",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7224182447",
  "pdf_url": "https://europepmc.org/articles/PMC13719956?pdf=render",
  "pmcid": "PMC13719956",
  "pmid": "42955194",
  "published": "2026-10-28",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/b6hy0cytajxqp.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:36Z",
      "native_id": "MED:42955194",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42955194"
    },
    {
      "first_seen": "2026-11-02T12:23:49Z",
      "native_id": "PMC13719956",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s11671-026-05076-6"
    }
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Cubosome integrated with polymeric carbon nitride and cisplatin: in vivo biodistribution and in vitro photodynamic therapy studies.",
  "title_text": "Cubosome integrated with polymeric carbon nitride and cisplatin: in vivo biodistribution and in vitro photodynamic therapy studies.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:55Z",
  "url": "https://research.draconitic.com/paper/b6hy0cytajxqp",
  "venue": "Discover nano",
  "versions": []
}