{
  "abstract": "INTRODUCTION: This study aimed to develop optimized prognostic cutoffs for amyloid‐β–positron emission tomography (Aβ‐PET) and Mini‐Mental State Examination (MMSE) that predict 3‐year progression from Clinical Dementia Rating Global (CDR‐Global) score 0.5 to 1.0 in mild cognitive impairment (MCI) participants and validate against cognitive decline/functional trajectories.\n\nMETHODS: We analyzed 454 CDR‐global = 0.5 Aβ‐positive (> 25 Centiloid [CL]) MCI participants from Australian Imaging Biomarkers and Lifestyle (AIBL) (N = 99) and Alzheimer's Disease Neuroimaging Initiative (ADNI) (N = 355), followed up to seven years. Youden index derived optimal Aβ‐PET and MMSE thresholds for 3‐year progression. Participants were stratified into four groups by combined Aβ‐PET/MMSE status. Adjusted Cox models (age, sex, education, apolipoprotein E [APOE] ε4) assessed progression to CDR‐Global score of 1.0 Alzheimer's disease (AD) dementia (confirmed with Aβ‐PET); adjusted linear mixed models assessed CDR Sum of Boxes (CDR‐SoB) and Preclinical Alzheimer's Cognitive Composite (PACC) trajectories.\n\nRESULTS: Optimal cutoffs were Aβ‐PET > 71 CL (hazard ratio [HR] = 2.67; 3‐year risk = 36.7%) and MMSE score of < 27 (HR = 2.27; 36.8%). The combined high Aβ/low MMSE group showed a 6.39‐fold risk and 47.8% 3‐year progression, with the steepest decline.\n\nDISCUSSION: Prognostically optimized Aβ‐PET and MMSE cutoffs improve 3‐year risk stratification beyond common diagnostic thresholds, supporting dual‐cutoff prognostic enrichment.",
  "abstract_shown": true,
  "affiliations": [
    "The Australian e‐Health Research Centre CSIRO Melbourne Victoria Australia",
    "School of Computing Technologies RMIT University Melbourne Victoria Australia",
    "The Australian e‐Health Research Centre CSIRO Brisbane Queensland Australia",
    "Centre for Precision Health Edith Cowan University Joondalup Western Australia Australia",
    "Collaborative Genomics and Translation Group School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia",
    "Center for Imaging of Neurodegenerative Diseases University of California‐San Francisco San Francisco California USA",
    "Alzheimer's Research Australia University of Western Australia Nedlands Western Australia Australia",
    "Centre for Healthy Ageing Health Futures Institute Murdoch University Murdoch Western Australia Australia",
    "School of Psychology Murdoch University Murdoch Western Australia Australia",
    "Cogstate Ltd Melbourne Victoria Australia",
    "Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA",
    "Florey Institute of Neuroscience and Mental Health The University of Melbourne Parkville Victoria Australia",
    "Department of Molecular Imaging & Therapy Austin Health Heidelberg Victoria Australia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Rosita Shishegar"
    },
    {
      "affs": [
        0
      ],
      "name": "Vincent Doré"
    },
    {
      "affs": [
        2
      ],
      "name": "Pierrick Bourgeat"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "James D. Doecke"
    },
    {
      "affs": [
        0
      ],
      "name": "Rodrigo Cánovas"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Simon M. Laws"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Tenielle Porter"
    },
    {
      "affs": [
        5
      ],
      "name": "Michael Weiner"
    },
    {
      "affs": [
        6
      ],
      "name": "Colin L. Masters"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Hamid R. Sohrabi"
    },
    {
      "affs": [
        2
      ],
      "name": "Jurgen Fripp"
    },
    {
      "affs": [
        9
      ],
      "name": "Paul Maruff"
    },
    {
      "affs": [
        10
      ],
      "name": "Victor L. Villemagne"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Christopher C. Rowe"
    },
    {
      "name": "for the Alzheimer's Disease Neuroimaging Initiativethe Australian Imaging BiomarkersLifestyle flagship study of ageing"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b70b8v1g87hre.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71892",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13740349/",
  "id": "b70b8v1g87hre",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://doi.org/10.1002/alz.71892",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
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  "openalex": "W7225411554",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.71892",
  "pmcid": "PMC13740349",
  "pmid": "42989479",
  "published": "2026-11-05",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/b70b8v1g87hre.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:21:37Z",
      "native_id": "PMC13740349",
      "source": "pmc",
      "url": "https://doi.org/10.1002/alz.71892"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Optimized amyloid‐β PET centiloid and cognitive cutoffs predict progression from mild cognitive impairment to Alzheimer's dementia",
  "title_text": "Optimized amyloid‐β PET centiloid and cognitive cutoffs predict progression from mild cognitive impairment to Alzheimer's dementia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:21:37Z",
  "url": "https://research.draconitic.com/paper/b70b8v1g87hre",
  "venue": "Alzheimer's & Dementia",
  "versions": []
}