{
  "abstract": "Background: Radiation-induced heart disease (RIHD) is a potential side effect of radiotherapy (RT) for thoracic tumors and breast cancers, often causing diastolic dysfunction, left ventricular hypertrophy (LVH), and fibrosis. Preimplantation factor (PIF), an embryonic immunomodulatory peptide, has shown protective effects against acute radiation syndrome. We investigated whether synthetic PIF (sPIF) could mitigate RIHD development in rats and tumor cell proliferation in human breast cancer cell lines.\n\nMethods: Adult male Sprague-Dawley rats were allocated into three experimental groups: vehicle-treated control, vehicle-treated RT (50 Gy, focused on the heart), and RT treated with sPIF, monitored at 1, 3, and 15 weeks. Endpoint assessments included transthoracic echocardiography, histopathology, qPCR, Western blotting, and UHPLC–MS/MS in the left ventricular (LV) samples. The effects of sPIF on hypertrophy, fibrosis, and proliferation were investigated in H9c2 cardiomyoblasts, human ventricular cardiac fibroblasts (HVCFs), and human breast carcinoma cells, respectively.\n\nResults: sPIF decreased LV expression of inflammatory markers at week 3 and attenuated RT-induced LVH and fibrosis, with reduced nitrotyrosine accumulation at week 15. sPIF suppressed angiotensin II–induced hypertrophy in H9c2 cells, inhibited transforming growth factor- β 1 (TGF β 1)–induced collagen-1 expression in HVCFs, and enhanced the anti-proliferative response to RT in human breast carcinoma cells.\n\nConclusions: These findings suggest the potential of sPIF as a cardioprotective agent for the management of RIHD and warrant further mechanistic investigations.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry and Interdisciplinary Center of Excellence, Albert Szent-Györgyi Medical School, University of Szeged",
    "Center for Biomedical Research and Translational Surgery, Medical University of Vienna",
    "Department of Oncotherapy, Albert Szent-Györgyi Medical School, University of Szeged",
    "Department of Pathophysiology, Albert Szent-Györgyi Medical School, University of Szeged",
    "Institute of Pharmacodynamics and Biopharmacy, University of Szeged",
    "Metabolic and Newborn Screening Laboratory, Department of Pediatrics, Albert Szent-Györgyi Medical School, University of Szeged",
    "Center for Anatomy and Cell Biology, Medical University of Vienna",
    "Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged",
    "Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre",
    "Single-Cell Technologies Ltd",
    "Institute for Molecular Medicine Finland (FIMM), University of Helsinki",
    "Institute of AI for Health, Helmholtz Zentrum München",
    "S.I.E.P. The Society for the Investigation of Early Pregnancy",
    "Obstetrics, Gynecology & Reproductive Sciences, Miller School of Medicine, University of Miami",
    "BioIncept, LLC (*sPIF Proprietary)",
    "Faculty of Health and Social Sciences, Gál Ferenc University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mónika Gabriella Kovács"
    },
    {
      "affs": [
        1
      ],
      "name": "Ana Isabel Antunes Goncalves"
    },
    {
      "affs": [
        2
      ],
      "name": "Zoltán Varga"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Réka Losonczi"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Klaudia Kupecz"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Dávid Volford"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Szonja Polett Pósa"
    },
    {
      "affs": [
        4
      ],
      "name": "Renáta Minorics"
    },
    {
      "affs": [
        5
      ],
      "name": "Zsolt Galla"
    },
    {
      "affs": [
        6
      ],
      "name": "Karin Zins"
    },
    {
      "affs": [
        7
      ],
      "name": "Anita Sejben"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "András Kriston"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Ferenc Kovács"
    },
    {
      "affs": [
        8,
        9,
        10,
        11
      ],
      "name": "Péter Horváth"
    },
    {
      "affs": [
        5
      ],
      "name": "Péter Monostori"
    },
    {
      "affs": [
        7
      ],
      "name": "Gábor Cserni"
    },
    {
      "affs": [
        4
      ],
      "name": "István Zupkó"
    },
    {
      "affs": [
        1
      ],
      "name": "Bruno K. Podesser"
    },
    {
      "affs": [
        12,
        13,
        14
      ],
      "name": "Eytan R. Barnea"
    },
    {
      "affs": [
        2
      ],
      "name": "Zsuzsanna Kahán"
    },
    {
      "affs": [
        1
      ],
      "name": "Attila Kiss"
    },
    {
      "affs": [
        1
      ],
      "name": "Peter Pokreisz"
    },
    {
      "affs": [
        0,
        3,
        15
      ],
      "name": "Márta Sárközy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b74dd5em8vbec.bib",
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  "doi": "10.3389/fcvm.2026.1946843",
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  "language": "eng",
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  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
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      "openalex",
      "2741|Effects of Radiation Exposure"
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  "pdf_url": "https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1946843/pdf",
  "pmcid": "PMC13719410",
  "pmid": "42964164",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
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  "subjects": [
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      "origin": "openalex:2741|Effects of Radiation Exposure",
      "subfield": "imaging"
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  ],
  "title": "Synthetic preimplantation factor ameliorates the severity of radiotherapy-induced heart disease in a rat model",
  "title_text": "Synthetic preimplantation factor ameliorates the severity of radiotherapy-induced heart disease in a rat model",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:28Z",
  "url": "https://research.draconitic.com/paper/b74dd5em8vbec",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}