{
  "abstract": "Gastroparesis is increasingly recognized in patients with Ehlers-Danlos syndrome (EDS), often driven by underlying autonomic dysfunction rather than pyloric pathology. We present a case of severe, refractory gastroparesis in a patient with EDS requiring post-pyloric enteral feeding and demonstrating no response to pyloric-directed therapy despite normal pyloric physiology on EndoFLIP. The patient ultimately improved following placement of a gastric electrical stimulator and optimization of enteral feeding strategies. This case highlights the importance of physiologic assessment in gastroparesis and demonstrates an association between normal pyloric physiology and limited response to pyloric-directed therapy in the setting of underlying neuropathic dysmotility.",
  "abstract_shown": true,
  "affiliations": [
    "Osteopathic Medicine, Lincoln Memorial University, Knoxville, USA.",
    "Gastroenterology, Borland Groover, Jacksonville, USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Katherine Stevens"
    },
    {
      "affs": [
        1
      ],
      "name": "Michael Herman"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b7nezkqabzc07.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.116640",
  "fulltext_url": "https://europepmc.org/articles/PMC13685580",
  "id": "b7nezkqabzc07",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910199",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2715|Gastrointestinal motility and disorders"
    ]
  ],
  "openalex": "W7213923426",
  "pdf_url": "https://europepmc.org/articles/PMC13685580?pdf=render",
  "pmcid": "PMC13685580",
  "pmid": "42910199",
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b7nezkqabzc07.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910199",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910199"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Gastrointestinal motility and disorders",
      "subfield": "general"
    }
  ],
  "title": "Refractory Gastroparesis in Ehlers-Danlos Syndrome: Failure of Pyloric-Directed Therapy Despite Normal Pyloric Physiology.",
  "title_text": "Refractory Gastroparesis in Ehlers-Danlos Syndrome: Failure of Pyloric-Directed Therapy Despite Normal Pyloric Physiology.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/b7nezkqabzc07",
  "venue": "Cureus",
  "versions": []
}