{
  "abstract": "A family of seven novel supramolecular photosensitizers comprising benzo[c][1,2,5]thiadiazole (BTZ) tethered calix[4]arene (C[4]) scaffolds has been synthesized using cross‐coupling strategies with selectively halogenated C[4]s, affording target compounds in high yield using facile purification. Their respective abilities to produce singlet oxygen has been evaluated through the photo‐oxidation of α‐terpinene, and structure–activity relationships established, probing factors such as cavity:photosensitizer ratio, distance of cavity to photosensitizer linker, and steric hindrance around the upper‐rim of the cavity. The presence of two C[4] cavities proximal to the photosensitizing BTZ unit provided vastly increased effectiveness in enhancing effective concentration through host:guest interactions, resulting in an eightfold increase in efficiency for the best‐performing member of the compound library benchmarked against a small‐molecule analogue, and reaching reaction completion in 1 h at 2.5 mol% loading. In contrast, systematically increasing the cavity:photosensitizing linker distance led to a reduction in improvement to 1.1‐fold relative to the small molecule analogue, confirming that these factors are pivotal in designing a suitable system based on the guest substrate.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Chemical Sciences, Heriot‐Watt University Riccarton, Edinburgh UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Leonardo Amicosante"
    },
    {
      "affs": [
        0
      ],
      "name": "Dominic Taylor"
    },
    {
      "affs": [
        0
      ],
      "name": "Cameron L. Campbell"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniel M. Lambden"
    },
    {
      "affs": [
        0
      ],
      "name": "Georgina M. Rosair"
    },
    {
      "affs": [
        0
      ],
      "name": "Filipe Vilela",
      "orcid": "0000-0003-2701-9759"
    },
    {
      "affs": [
        0
      ],
      "name": "Scott J. Dalgarno",
      "orcid": "0000-0001-7831-012X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b7qhjtaf94asd.bib",
  "cited_by": 0,
  "doi": "10.1002/chem.71443",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729942/",
  "id": "b7qhjtaf94asd",
  "issns": [
    "0947-6539",
    "1521-3765"
  ],
  "landing_url": "https://doi.org/10.1002/chem.71443",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1605|Supramolecular Chemistry and Complexes"
    ]
  ],
  "openalex": "W7172270213",
  "pdf_url": null,
  "pmcid": "PMC13729942",
  "pmid": "42545060",
  "published": "2026-08-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b7qhjtaf94asd.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:40Z",
      "native_id": "PMC13729942",
      "source": "pmc",
      "url": "https://doi.org/10.1002/chem.71443"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Supramolecular Chemistry and Complexes",
      "subfield": "organic"
    }
  ],
  "title": "Benzo[c][1,2,5]Thiadiazole Linkers Enhance the Effectiveness of Cavity‐Containing Supramolecular Photocatalysts",
  "title_text": "Benzo[c][1,2,5]Thiadiazole Linkers Enhance the Effectiveness of Cavity‐Containing Supramolecular Photocatalysts",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:40Z",
  "url": "https://research.draconitic.com/paper/b7qhjtaf94asd",
  "venue": "Chemistry (Weinheim an Der Bergstrasse, Germany)",
  "versions": []
}