{
  "abstract": "Background: Drug-coated balloon (DCB) therapy for in-stent restenosis (ISR) relies on efficient drug transfer during balloon–artery contact. Surface micro-patterning has been proposed to enhance transfer efficiency without altering the antiproliferative drug. This study evaluated a linear micro-patterned DCB (LMDCB) compared with a comparator paclitaxel-coated DCB in a porcine coronary ISR model. Methods: ISR was induced by bare-metal stent implantation followed by a 4-week maturation period. In two prespecified cohorts (1 month: 10 animals, 20 segments; 3 months: 4 animals, 8 segments), paired ISR segments within each animal were treated with LMDCB or a comparator paclitaxel-coated DCB (3.0 µg/mm2). Endpoints included quantitative coronary angiography (QCA), optical coherence tomography (OCT), and histology. Results: At 1 month, LMDCB demonstrated a larger minimum lumen diameter (2.3 ± 0.2 mm vs 1.9 ± 0.4 mm; p = 0.019) and lower percent diameter stenosis (13.3 ± 4.8% vs 23.7 ± 9.3%; p = 0.003). OCT showed lower mean neointimal thickness (0.2 ± 0.1 mm vs 0.3 ± 0.1 mm; p = 0.008). Histology showed lower neointimal area (2.4 ± 0.7 mm2 vs 2.9 ± 1.1 mm2; p = 0.011) and percent area stenosis (36.6 ± 10.4% vs 44.4 ± 17.8%; p = 0.013), with comparable vascular healing indices. In the independent 3-month cohort, QCA and OCT findings were similar between groups. Exploratory histology in a limited subset suggested a larger lumen and lower percent area stenosis with LMDCB. Conclusions: In this porcine coronary ISR model, LMDCB was associated with reduced neointimal proliferation and improved luminal dimensions at 1 month compared with a comparator paclitaxel-coated DCB, without impaired vascular healing. In a separate 3-month cohort, imaging findings were comparable between devices, while histology remained exploratory.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Cardiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea",
    "Yonsei University College of Medicine, Seoul, Korea",
    "Integrative Research Center for Cerebrovascular and Cardiovascular Diseases, Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea",
    "Cardiovascular Product Evaluation Center, Yonsei University College of Medicine, Seoul, Korea",
    "Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea",
    "Division of Cardiology, Yongin Severance Hospital, Yonsei University College of Medicine, Gyeonggi-do, Korea",
    "Division of Cardiology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea",
    "Department of Mechanical Engineering, Yonsei University, Seoul, Korea"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Seunghwan Kim"
    },
    {
      "affs": [
        1
      ],
      "name": "Seul-Gee Lee"
    },
    {
      "affs": [
        2
      ],
      "name": "Joonoh Park"
    },
    {
      "affs": [
        3
      ],
      "name": "Jino Park"
    },
    {
      "affs": [
        4
      ],
      "name": "Dong-Kie Kim"
    },
    {
      "affs": [
        5
      ],
      "name": "Ki-Hun Kim"
    },
    {
      "affs": [
        6
      ],
      "name": "Doo-Il Kim"
    },
    {
      "affs": [
        7
      ],
      "name": "Se-Il Park"
    },
    {
      "name": "Ok-Hee Jeon"
    },
    {
      "name": "Yong-Jun Lee"
    },
    {
      "name": "Oh-Hyun Lee"
    },
    {
      "name": "Dong-Eon Kim"
    },
    {
      "name": "WonHyoung Ryu"
    },
    {
      "name": "Jung-Sun Kim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b9f9403zrfjbp.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0359232",
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  "id": "b9f9403zrfjbp",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0359232",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Coronary Interventions and Diagnostics"
    ],
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  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0359232&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-25",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/b9f9403zrfjbp.ris",
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    {
      "first_seen": "2026-10-30T12:17:43Z",
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      "url": "https://doi.org/10.1371/journal.pone.0359232"
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  "subjects": [
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  "title": "Surface micro-patterned drug-coated balloon enhances early biological efficacy in a porcine coronary in-stent restenosis model",
  "title_text": "Surface micro-patterned drug-coated balloon enhances early biological efficacy in a porcine coronary in-stent restenosis model",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/b9f9403zrfjbp",
  "venue": "PLOS One",
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}