{
  "abstract": "Vaccine-induced humoral immunity emerges from complex interactions among competing B-cell populations and antibody production in response to antigen exposure, yet the mechanisms governing these interactions remain only partially understood. We developed a mechanistic mathematical model that integrates vaccine regimen features, immunogen kinetics, multiclass B-cell dynamics, and germinal center processes. The model was calibrated to data from the G001 HIV vaccine trial evaluating eOD-GT8, a germline-targeting immunogen designed to activate VRC01-class precursor B cells capable of developing into broadly neutralizing antibody-producing cells. The model reproduced key features of the observed B-cell and antibody responses, enabled estimation of class-specific activation and competition parameters, and supported investigation of the identifiability of competition parameters. Activation rates varied across B-cell classes, with memory B cells exhibiting substantially higher activation rates than naive B cells. Importantly, competition was stronger within than between classes, with the strongest competition occurring among VRC01-class B cells. These findings suggest that class-specific differences in activation and competition shape the magnitude and composition of vaccine-induced humoral response and may influence the expansion of broadly neutralizing antibody precursors. More broadly, the model provides a quantitative framework for dissecting multiclass B-cell competition and antibody responses, and for evaluating how vaccination strategies shape humoral immunity.",
  "abstract_shown": true,
  "affiliations": [
    "Fred Hutchinson Cancer Center"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "S. A. Iyaniwura"
    },
    {
      "name": "B. T. Mayer"
    },
    {
      "name": "W. Hahn"
    },
    {
      "name": "S.-Y. Kim"
    },
    {
      "name": "Y. Huang"
    },
    {
      "name": "O. Hyrien"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b9r2r488s5ekr.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.14.759230",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759230v1.full",
  "id": "b9r2r488s5ekr",
  "issns": [
    "2692-8205"
  ],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759230v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ],
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2403|T-cell and B-cell Immunology"
    ]
  ],
  "openalex": "W7223119617",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759230v1.full.pdf",
  "pmcid": "PMC13738377",
  "pmid": "42995777",
  "published": "2026-10-14",
  "publisher": "Cold Spring Harbor Laboratory Preprints",
  "ris": "https://research.draconitic.com/paper/b9r2r488s5ekr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:50Z",
      "native_id": "10.64898/2026.10.14.759230",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759230v1"
    },
    {
      "first_seen": "2026-11-09T12:23:22Z",
      "native_id": "PMC13738377",
      "source": "pmc",
      "url": "https://doi.org/10.64898/2026.10.14.759230"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "A Multiclass Mechanistic Model of Vaccine-Induced Humoral Response",
  "title_text": "A Multiclass Mechanistic Model of Vaccine-Induced Humoral Response",
  "type": "preprint",
  "updated_at": "2026-11-09T12:23:22Z",
  "url": "https://research.draconitic.com/paper/b9r2r488s5ekr",
  "venue": "bioRxiv",
  "versions": []
}