{ "abstract": "Purpose\n\nIn patients with hematological malignancies and central venous catheters (CVC) men have a higher risk for CVC related bloodstream infections (CRBSI) than women. Hence, preventive strategies such as earlier CVC removal may reduce the overall CRBSI (oCRBSI) rate.\n\nMethods\n\nA randomized simulation using data from a CVC registry was performed. Data were derived from unselected patients with hematological or oncological diseases and a CVC. Patients were randomized to an experimental (EXP-G) or control group (CON-G). For the men in the EXP-G, one-day increments of an earlier CVC removal were simulated based on actual data and compared to men in the CON-G without simulation. The primary endpoint was oCRBSI rate.\n\nResults\n\nUnderlying diseases were mainly hematological malignancies (87.3%). In the male patients with a median CVC in situ time of 13 days, the oCRBSI rate was 7.3% (103/1408), with 7.3% (53/729) in the EXP-G and 7.4% (50/679) in the CON-G. In the EXP-G, simulated shortening of CVC time by 1 day in men resulted in an oCRBSI rate of 5.2% compared with 7.4% in the CON-G (p = 0.12). Shortening CVC time by 2 days led to an oCRBSI rate of 4% (p = 0.008); the corresponding median CVC time was 11 days. A 3-day shortening further to 10 days reduced the oCRBSI rate to 2.7% (p < 0.001). Women from the same registry showed a 3.3% (30/920) oCRBSI rate after 12 days.\n\nConclusion\n\nIn conclusion, shortening the CVC dwell time in men by 2 or 3 days, corresponding to a CVC duration of 10–11 days, reduces the CRBSI rate in men and mitigates the higher risk, compared to women.\n\nClinical Trial Registration: SECRECY (Study to Evaluate Central Venous Catheter-related Infections in Hematology and Oncology) was registered within the German Clinical Trial Register (DRKS; no. DRKS00006551) on 29 September 2014.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s15010-026-02888-7.", "abstract_shown": true, "affiliations": [ "Department of Hematology and Medical Oncology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany", "Department of Internal Medicine I, University Hospital of Cologne, Cologne, Germany", "Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany", "Department of Hematology, Oncology and Palliative Care, Robert Bosch Hospital, Stuttgart, Germany", "Department of Internal Medicine II, Passau Hospital, Passau, Germany", "Department of Internal Medicine II, Schwarzwald – Baar – Klinikum, Villingen-Schwenningen, Germany", "Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany", "Center for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf (ABCD), Germany", "Clinic of Hematology, Oncology, Pneumology, Nephrology and Diabetology, Medical University Lausitz – Carl Thiem (MUL-CT), Cottbus, Germany", "Department of Hematology and Oncology, Sozialstiftung Bamberg, Bamberg, Germany", "Comprehensive Cancer Center Mainfranken (CCC MF), University Hospital of Würzburg, Würzburg, Germany", "Department of Internal Medicine I, Klinikum Mutterhaus der Borromaerinnen, Trier, Germany", "Oncology, Hemostaseology and Palliative Care, University Clinic for Hematology, University of Bochum, Minden, Germany", "Department of Hematology and Oncology, Red Cross Hospital Munich, Munich, Germany", "Medical Faculty, Department of Hematology, Oncology, Cell and Radiation Therapy, Otto von Guericke University Magdeburg, Magdeburg, Germany" ], "article_type": "research article", "arxiv": null, "author_total": 25, "authors": [ { "affs": [ 0 ], "name": "Oliver Kriege", "orcid": "0000-0002-3274-7390" }, { "affs": [ 1 ], "name": "Boris Böll", "orcid": "0000-0002-6432-0981" }, { "affs": [ 2 ], "name": "Nicole Brüder", "orcid": "0000-0002-2880-070X" }, { "affs": [ 3 ], "name": "Nicola Giesen", "orcid": "0000-0002-9615-2564" }, { "affs": [ 4 ], "name": "Julia Lanznaster", "orcid": "0000-0002-6592-156X" }, { "affs": [ 5 ], "name": "Susanne Mertins" }, { "affs": [ 6, 7 ], "name": "Antrea Minti" }, { "affs": [ 1 ], "name": "Jan-Hendrik Naendrup", "orcid": "0000-0002-6420-7938" }, { "affs": [ 8 ], "name": "Martin Schmidt-Hieber", "orcid": "0000-0002-3071-6945" }, { "affs": [ 9, 10 ], "name": "Ruth Seggewiss-Bernhardt", "orcid": "0000-0001-7488-4791" }, { "affs": [ 11 ], "name": "Philipp Weber", "orcid": "0009-0006-5025-254X" }, { "affs": [ 12 ], "name": "Kai Wille", "orcid": "0000-0002-7682-8563" }, { "affs": [ 6, 7 ], "name": "Jens Panse", "orcid": "0000-0001-6316-3112" }, { "affs": [ 13 ], "name": "Marcus Hentrich", "orcid": "0000-0001-5622-348X" }, { "affs": [ 14 ], "name": "Enrico Schalk", "orcid": "0000-0003-1892-5098" }, { "name": "Sabine Einhell" }, { "name": "Sabine Einhell" }, { "name": "Eva Fiegle" }, { "name": "Pierre Kremer" }, { "name": "Timo Schmitt" }, { "name": "Sebastian Schulz" }, { "name": "Christoph Schüssler" }, { "name": "Daniela Tölle" }, { "name": "Benedikt W. Pelzer" }, { "name": "Judit Grans-Siebel" } ], "bibtex": "https://research.draconitic.com/paper/b9vy5enna0z6v.bib", "cited_by": 0, "doi": "10.1007/s15010-026-02888-7", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13727808/", "id": "b9vy5enna0z6v", "issns": [ "0300-8126", "1439-0973" ], "landing_url": "https://doi.org/10.1007/s15010-026-02888-7", "language": "en", "licence": "CC-BY-4.0", "licence_label": "CC BY 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Brief Report" ], [ "openalex", "3604|Central Venous Catheters and Hemodialysis" ] ], "openalex": "W7167910909", "pdf_url": "https://link.springer.com/content/pdf/10.1007/s15010-026-02888-7.pdf", "pmcid": "PMC13727808", "pmid": "42430117", "published": "2026-07-10", "publisher": null, "ris": "https://research.draconitic.com/paper/b9vy5enna0z6v.ris", "sources": [ { "first_seen": "2026-11-06T12:23:37Z", "native_id": "PMC13727808", "source": "pmc", "url": "https://doi.org/10.1007/s15010-026-02888-7" } ], "subjects": [ { "field": "medicine", "origin": "journal-openalex:F27", "subfield": "general" } ], "title": "Shortening of central venous catheter time in men with hematological and oncological diseases for prevention of central venous catheter-related bloodstream infections: a target-trial-emulation study", "title_text": "Shortening of central venous catheter time in men with hematological and oncological diseases for prevention of central venous catheter-related bloodstream infections: a target-trial-emulation study", "type": "peer-reviewed", "updated_at": "2026-11-07T12:20:55Z", "url": "https://research.draconitic.com/paper/b9vy5enna0z6v", "venue": "Infection", "versions": [] }