{
  "abstract": "About 10% of neuroendocrine tumors (NETs) can occur in the context of several different hereditary tumor syndromes, and, in a not negligible number of cases, their diagnosis precedes the clinical identification of the hereditary syndrome. In this context, the role of a pathologist can be crucial in identifying these sentinel cases. Indeed, early recognition of inherited NETs has significant clinical value, both for guiding therapeutic strategies and for managing at-risk family members. Modern pathologists play a central role not only in the accurate diagnosis and subtyping of NETs but also in recognizing specific morphologic features that may point to a germline etiology. When morphology does not show peculiar features suggestive of a hereditary context, integrating morphology with clinical context may, however, help identify appropriate genetic testing. In the present paper, we provide an organ-based overview of the most important morphologic and immunohistochemical features, along with their molecular correlates, of pituitary, parathyroid, thoracic, and digestive NETs arising in the context of hereditary tumor syndromes.",
  "abstract_shown": true,
  "affiliations": [
    "Departments of Biomedical Sciences, Humanitas University, Milan",
    "Pathology Service, Istituti di Ricovero e Cura a Carattere Scientifico, Humanitas Research Hospital, Milan",
    "Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona",
    "ARC-NET Research Center, University of Verona, Verona",
    "Pathology, TUM School of Medicine and Health, Technical University Munich, Munich, Germany",
    "Medicine and Technological Innovation, Unit of Pathology",
    "Medicine and Technological Innovation, Hereditary Cancer Research Center, University of Insubria",
    "Unit of Pathology, University Hospital (ASST Sette Laghi), Varese, Italy"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Silvia Uccella"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Claudio Luchini"
    },
    {
      "affs": [
        4
      ],
      "name": "Atsuko Kasajima"
    },
    {
      "affs": [
        4
      ],
      "name": "Günter Klöppel"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Stefano La Rosa",
      "orcid": "0000-0003-1941-2403"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ba1bqnhwrmj2y.bib",
  "cited_by": 0,
  "doi": "10.1097/pap.0000000000000551",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13716303/",
  "id": "ba1bqnhwrmj2y",
  "issns": [
    "1072-4109",
    "1533-4031"
  ],
  "landing_url": "https://doi.org/10.1097/pap.0000000000000551",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Articles"
    ],
    [
      "openalex",
      "2713|Neuroendocrine Tumor Research Advances"
    ]
  ],
  "openalex": "W7212151516",
  "pdf_url": null,
  "pmcid": "PMC13716303",
  "pmid": "42720556",
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ba1bqnhwrmj2y.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:23:20Z",
      "native_id": "PMC13716303",
      "source": "pmc",
      "url": "https://doi.org/10.1097/pap.0000000000000551"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Neuroendocrine Tumor Research Advances",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "The Role of the Surgical Pathologist in the Recognition of Hereditary Neuroendocrine Tumors",
  "title_text": "The Role of the Surgical Pathologist in the Recognition of Hereditary Neuroendocrine Tumors",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:20Z",
  "url": "https://research.draconitic.com/paper/ba1bqnhwrmj2y",
  "venue": "Advances in Anatomic Pathology",
  "versions": []
}