{
  "abstract": "Introduction: Haemophilia impacts health and quality of life. Advances in treatments such as factor replacement therapy (FRT), bispecific monoclonal antibody (BS-mAb), gene therapy (GT), rebalancing treatment and high sustained factor necessitate understanding patient preferences to inform therapeutic strategies. Aim: This study quantified trade-offs of French adult patients with moderate-to-severe haemophilia A/B when choosing between two treatments. Methods: A non-interventional, web-based survey using the threshold technique was conducted. Six treatment attributes were identified through systematic review, semi-structured patient interviews and clinical expert consultations: administration frequency, number of annual bleeds, duration of prophylaxis discontinuation, duration of long-term safety data, joint pain after 6 months and preparation/administration requirements. Thresholds were interpreted under fixed attributes assumptions. Results: Of the 95 recruited patients, 86 were eligible for analysis. Most participants were male (97%), aged 41 on average; 88% had haemophilia A, 87% severe cases. On average, patients accepted 1.1 (median: 0) annual bleeds to switch from BS-mAb-like to high sustained factor-like profiles, 1.5 (median: 0.5) to switch from BS-mAb-like to rebalancing treatment-like profiles and 3.3 to switch from FRT-like to rebalancing treatment-like profiles, holding all else constant. To switch from FRT-like to GT-like profile, patients were willing to accept 4.8 annual bleeds or 12.5 years of prophylaxis discontinuation (median: 1). Patients required lower annual bleeds and longer prophylaxis discontinuation when switching from BS-mAb-like to GT-like profile (3.5 annual bleeds or 14.3 years of prophylaxis discontinuation [median: 2]). Conclusions: Treatment preferences among French patients with haemophilia are highly individualized, reflecting nuanced trade-offs between bleeding risk, treatment convenience and long-term safety that vary according to current therapeutic strategies and individual patient priorities. These findings underscore the importance of shared, personalized decision-making in contemporary haemophilia care.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Yesim Dargaud"
    },
    {
      "name": "Yasmine Fahfouhi"
    },
    {
      "name": "Monia Ezzalfani"
    },
    {
      "name": "Astrid Foix Colonier"
    },
    {
      "name": "Alaeddine Sidhom"
    },
    {
      "name": "Aline Gauthier"
    },
    {
      "name": "Jérémie Rudant"
    },
    {
      "name": "Meriem Kessouri"
    },
    {
      "name": "Nicolas Giraud"
    },
    {
      "name": "Benoit Guillet"
    },
    {
      "name": "Anaïs Reynaud"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ba3zpm1hb7atd.bib",
  "cited_by": 0,
  "doi": "10.1111/hae.70298",
  "fulltext_url": null,
  "id": "ba3zpm1hb7atd",
  "issns": [
    "1351-8216",
    "1365-2516"
  ],
  "landing_url": "https://hal.science/hal-05778903v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2720|Hemophilia Treatment and Research"
    ]
  ],
  "openalex": "W7212255492",
  "pdf_url": "https://hal.science/hal-05778903/document",
  "pmcid": null,
  "pmid": "42723436",
  "published": "2026-10-05",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/ba3zpm1hb7atd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:47Z",
      "native_id": "hal-05778903",
      "source": "hal",
      "url": "https://hal.science/hal-05778903v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Patient Preferences for the Treatment of Haemophilia A and B in France",
  "title_text": "Patient Preferences for the Treatment of Haemophilia A and B in France",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:47Z",
  "url": "https://research.draconitic.com/paper/ba3zpm1hb7atd",
  "venue": "Haemophilia",
  "versions": []
}