{
  "abstract": "Objective Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the standard procedure for diagnosing mediastinal and hilar lymphadenopathy, its diagnostic yield for sarcoidosis remains suboptimal due to nodal fibrosis. Endobronchial ultrasound-guided intranodal forceps biopsy (EBUS-IFB) has emerged as a promising adjunctive technique; however, concerns remain regarding the potential for crush artifacts when using mini-forceps. This study aimed to evaluate the histological specimen quality, diagnostic utility, and safety of EBUS-IFB in patients with suspected sarcoidosis in a single institution.Methods We retrospectively analyzed 11 consecutive patients with suspected sarcoidosis who underwent EBUS-IFB after EBUS-TBNA at a single center. We assessed the specimen quality, diagnostic yield, and safety. Two pathologists independently evaluated the specimens using a validated scoring system focusing on the amount of cellular material, background blood, degree of cellular degeneration and trauma, and retention of normal architecture.Results EBUS-IFB yielded significantly higher-quality specimens than EBUS-TBNA (median total score, 7.0 vs. 4.0; p = 0.01). Notably, EBUS-IFB specimens demonstrated well-preserved tissue architecture without significant crush artifacts and significantly less blood contamination (p = 0.006). The overall diagnostic yield was 81.8% (9 of 11), and definitive diagnoses of sarcoidosis were obtained by EBUS-IFB alone in six cases. No procedure-related complications were noted.Conclusions Despite concerns regarding crush artifacts, EBUS-IFB provides high-quality, structurally intact histological specimens with minimal blood contamination compared to EBUS-TB. EBUS-IFB is a safe and effective adjunctive modality that successfully compensates for the limitations of fine-needle aspiration in sampling fibrotic lymph nodes.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Suzuka Matsuoka"
    },
    {
      "name": "Yuki Takigawa"
    },
    {
      "name": "Ken Sato"
    },
    {
      "name": "Mayu Goda"
    },
    {
      "name": "Keisuke Shiraha"
    },
    {
      "name": "Jun Nishimura"
    },
    {
      "name": "Hiromi Watanabe"
    },
    {
      "name": "Kenichiro Kudo"
    },
    {
      "name": "Tetsuya Isoda"
    },
    {
      "name": "Yoko Shinno"
    },
    {
      "name": "Keiichi Fujiwara"
    },
    {
      "name": "Takuo Shibayama"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ba6q8f59wav03.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7892-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7892-26/_article",
  "id": "ba6q8f59wav03",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7892-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2737|Sarcoidosis and Beryllium Toxicity Research"
    ]
  ],
  "openalex": "W7212882505",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7892-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ba6q8f59wav03.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7892-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7892-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Sarcoidosis and Beryllium Toxicity Research",
      "subfield": "physiology"
    }
  ],
  "title": "Role of EBUS-IFB in Providing High-quality Pathological Samples for a Sarcoidosis Diagnosis",
  "title_text": "Role of EBUS-IFB in Providing High-quality Pathological Samples for a Sarcoidosis Diagnosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/ba6q8f59wav03",
  "venue": "Internal Medicine",
  "versions": []
}