{
  "abstract": "Ischemic stroke triggers acidosis, glutamate excitotoxicity and oxidative stress, which converge to disturb ionic homeostasis through several cation channels, including acid-sensing ion channel 1a (ASIC1a), N-methyl-D-aspartate receptors (NMDARs) and transient receptor potential melastatin (TRPM) channels. Emerging evidence suggests that ASIC1a functions as a context-dependent integrating node: protons directly gate ASIC1a, glutamate and bilirubin-associated signaling can modulate ASIC1a-dependent injury pathways. ASIC1a directly couples with NMDAR-dependent signaling and indirectly engages TRPM-associated pathways. Here, we discuss the mechanistic basis, therapeutic potential and unresolved questions regarding ASIC1a-associated signaling in ischemic brain injury.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China. ilaike@sjtu.edu.cn.",
    "Program in Neuroscience and Mental Health, SickKids Research Institute, Toronto, M5G 1X8, Canada. luyang.wang@utoronto.ca.",
    "Department of Physiology, University of Toronto, Toronto, M5S 1A1, Canada. luyang.wang@utoronto.ca."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ke Lai"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Lu-Yang Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/baapd1238s3n1.bib",
  "cited_by": 0,
  "doi": "10.1007/s00424-026-03225-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13680530",
  "id": "baapd1238s3n1",
  "issns": [
    "0031-6768",
    "1432-2013"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897310",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2809|Ion Channels and Receptors"
    ]
  ],
  "openalex": "W7222976207",
  "pdf_url": "https://europepmc.org/articles/PMC13680530?pdf=render",
  "pmcid": "PMC13680530",
  "pmid": "42897310",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/baapd1238s3n1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42897310",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897310"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2809|Ion Channels and Receptors",
      "subfield": "neuroscience"
    }
  ],
  "title": "ASIC1a as an integrating node in ischemic neurotoxicity: crosstalk with NMDAR and TRPM signaling.",
  "title_text": "ASIC1a as an integrating node in ischemic neurotoxicity: crosstalk with NMDAR and TRPM signaling.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/baapd1238s3n1",
  "venue": "Pflugers Archiv : European journal of physiology",
  "versions": []
}