{
  "abstract": "An efficient coumarin-based fluorescent probe, HCPD, was synthesized via condensation of 7-diethylamino-4-hydroxycoumarin aldehyde with o-phenylenediamine. The structure of the probe was confirmed by FT-IR, NMR and HRMS studies. The probe, HCPD exhibited aggregation-induced emission (AIE) characteristics in a THF-water mixture, showing enhanced emission at 80% water fraction. The probe functions as a molecular switch for the sensitive detection of the environmentally and biologically significant metal ion Co²⁺ at the nanomolar level. HCPD emits green emission at 500 nm which selectively detects Co²⁺ ions in a DMF/Tris-HCl buffer system (9 : 1, v/v) through an emission \"turn-off\" response, attributed to paramagnetic quenching. In addition, Job's plot and HRMS analysis established a 1 : 1 binding stoichiometry between HCPD and Co²⁺ ions. The probe demonstrated remarkable sensitivity with a low detection limit of 11.7 nM and a binding constant of 3.6798 × 10⁴ M⁻¹. Notably, the emission of the HCPD-Co²⁺ ensemble was restored upon the addition of ATP over various competing anions, enabling reversible sensing behavior not previously reported in the reversibility of Co²⁺ ions. The regeneration capability of the probe facilitated practical on-site applications, including paper strips, cotton swabs and the construction of an IMPLICATION logic gate circuit. Furthermore, HCPD was also successfully applied in bio-imaging studies of MDA-MB-231 breast cancer cell lines, highlighting its biological relevance. Overall, HCPD represents a highly sensitive and reversible dual-responsive fluorescent probe for Co²⁺ and ATP detection with significant environmental and biological applications.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Bharathiar University, 641046 Coimbatore Tamil Nadu India.",
    "Department of Biotechnology, Bharathiar University, 641046 Coimbatore Tamil Nadu India mpandian@gmail.com bmurugesapandian@buc.edu.in."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rajendran Kishore Kumar",
      "orcid": "0009-0000-4173-1529"
    },
    {
      "affs": [
        1
      ],
      "name": "Suryaa Manoharan",
      "orcid": "0000-0002-9777-4242"
    },
    {
      "affs": [
        1
      ],
      "name": "Ekambaram Perumal",
      "orcid": "0000-0003-2159-8198"
    },
    {
      "affs": [
        0
      ],
      "name": "Balasubramanian Murugesapandian",
      "orcid": "0000-0002-7096-9816"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/baxr7x20n146z.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08250e",
  "fulltext_url": "https://europepmc.org/articles/PMC13679144",
  "id": "baxr7x20n146z",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42899141",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1607|Molecular Sensors and Ion Detection"
    ]
  ],
  "openalex": "W7222986547",
  "pdf_url": "https://europepmc.org/articles/PMC13679144?pdf=render",
  "pmcid": "PMC13679144",
  "pmid": "42899141",
  "published": "2026-10-19",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/baxr7x20n146z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42899141",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42899141"
    },
    {
      "first_seen": "2026-11-07T12:23:34Z",
      "native_id": "PMC13679144",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra08250e"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Molecular Sensors and Ion Detection",
      "subfield": "physical"
    }
  ],
  "title": "A multifunctional bishydroxycoumarin conjugate exhibiting AIE characteristics and tandem Co²⁺/ATP detection with logic gate operations, on-site sensing and bioimaging applications.",
  "title_text": "A multifunctional bishydroxycoumarin conjugate exhibiting AIE characteristics and tandem Co²⁺/ATP detection with logic gate operations, on-site sensing and bioimaging applications.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:02Z",
  "url": "https://research.draconitic.com/paper/baxr7x20n146z",
  "venue": "RSC advances",
  "versions": []
}