{
  "abstract": "Our understanding of cell division control traditionally comes via using liquid broths or 2D flat-plate cultures - which cannot recapitulate the complex visco-elasto-plastic properties of natural habitats such as tissues, mucus, and soil. Consequently, how such regimes of physical confinement influence proliferative growth remains poorly understood. Here, using engineered, mechanically tunable and transparent growth matrices, we directly visualize yeast budding and division across 3D viscoelastic regimes. We discover that elevated physical confinement drastically prolongs budding intervals without any physiological defects or activating global regulatory programs. Remarkably, extended cell division times are not associated with transcriptional or proteomic signatures of mechanosensation or cell cycle regulation. Rather, 3D confinement physically constrains the volumetric growth of incipient buds - manifesting as delayed cell cycle progression. Hence, our findings establish that physical constrainment regulates eukaryotic cell division.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "M. Sreepadmanabh",
      "orcid": "0000-0003-3492-0203"
    },
    {
      "name": "Mridul Gautam"
    },
    {
      "name": "Nikita Bagade"
    },
    {
      "name": "Sunil Laxman",
      "orcid": "0000-0002-0861-5080"
    },
    {
      "name": "Tapomoy Bhattacharjee",
      "orcid": "0000-0001-8899-1379"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bbepm7n3acfws.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78414-y",
  "fulltext_url": "https://europepmc.org/articles/PMC13675237",
  "id": "bbepm7n3acfws",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78414-y",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1307|Cellular Mechanics and Interactions"
    ]
  ],
  "openalex": "W7222716440",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78414-y.pdf",
  "pmcid": "PMC13675237",
  "pmid": "42888212",
  "published": "2026-10-16",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/bbepm7n3acfws.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-78414-y",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78414-y"
    },
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42888212",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42888212"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Cellular Mechanics and Interactions",
      "subfield": "cell-biology"
    }
  ],
  "title": "3D confinement physically regulates cell cycle progression in budding yeast",
  "title_text": "3D confinement physically regulates cell cycle progression in budding yeast",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/bbepm7n3acfws",
  "venue": "Nature Communications",
  "versions": []
}