{
  "abstract": "The asymmetric unit of the title compound, C26H24FN3O3, contains one mol-ecule comprising a tricyclic chromeno[2,3-d]pyrimidine core formed by fused cyclo-hexa-none, pyran and pyrimidine rings. The sp3-hybridized methine carbon atom bears a 2-meth-oxy-phenyl substituent, which is oriented almost perpendicular to the pyran ring, with a dihedral angle of 84.11 (5)°. The 4-fluoro-phenyl-amino substituent is twisted relative to the pyrimidine ring, as indicated by the C-C-N-C torsion angle of 29.79 (18)° and the dihedral angle of 27.59 (4)° In the crystal, C-H⋯O and C-H⋯F hydrogen bonds link the mol-ecules into supra-molecular chains extending diagonally within the ac plane. An intra-molecular N-H⋯O hydrogen bond is also present between the amino and meth-oxy groups.",
  "abstract_shown": true,
  "affiliations": [
    "School of Agriculture and Science, Discipline of Chemistry, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.",
    "Department of Chemical Sciences, Olabisi Onabanjo University, Ago-Iwoye, Nigeria.",
    "Department of Chemical Sciences, University of Johannesburg, PO Box 524 Auckland, Park, Johannesburg, 2006, South Africa."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Adesola A Adeleke",
      "orcid": "0000-0001-9287-5960"
    },
    {
      "affs": [
        0
      ],
      "name": "Sizwe J Zamisa",
      "orcid": "0000-0003-1968-381X"
    },
    {
      "affs": [
        2
      ],
      "name": "Orpah Zinyemba"
    },
    {
      "affs": [
        0
      ],
      "name": "Bernard Omondi"
    },
    {
      "affs": [
        0
      ],
      "name": "Olatunde S Olatunji"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bbssrrbrjtanm.bib",
  "cited_by": 0,
  "doi": "10.1107/s2414314626010461",
  "fulltext_url": "https://europepmc.org/articles/PMC13741261",
  "id": "bbssrrbrjtanm",
  "issns": [
    "2414-3146"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997229",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1604|Crystal structures of chemical compounds"
    ]
  ],
  "openalex": "W7224875590",
  "pdf_url": "https://europepmc.org/articles/PMC13741261?pdf=render",
  "pmcid": "PMC13741261",
  "pmid": "42997229",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bbssrrbrjtanm.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:42Z",
      "native_id": "MED:42997229",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997229"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1604|Crystal structures of chemical compounds",
      "subfield": "inorganic"
    }
  ],
  "title": "4-[(4-Fluoro-phen-yl)amino]-5-(2-meth-oxy-phen-yl)-8,8-dimethyl-6,7,8,9-tetra-hydro-5H-chromeno[2,3-d]pyrimidin-6-one.",
  "title_text": "4-[(4-Fluoro-phen-yl)amino]-5-(2-meth-oxy-phen-yl)-8,8-dimethyl-6,7,8,9-tetra-hydro-5H-chromeno[2,3-d]pyrimidin-6-one.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:42Z",
  "url": "https://research.draconitic.com/paper/bbssrrbrjtanm",
  "venue": "IUCrData",
  "versions": []
}