{
  "abstract": "Bioelectronic medicine enables direct interfacing with native cell populations but remains limited by poor long-term integration and minimal interaction with non-electroactive cells. In contrast, regenerative medicine promotes tissue integration yet lacks bidirectional functionality. Here, we present a hybrid implantation methodology combining a tissue engineered cellularized hydrogel with a neural recording array for simultaneous delivery into the brain via needle placement. This approach enables co-localized transplantation of cells and electronics while minimizing surgical footprint. Post-implantation electrophysiological recordings show functional integration with surrounding neural tissue, demonstrating the feasibility of this platform for coupled bioelectronic sensing and regenerative capabilities. The online version contains supplementary material available at https://doi.org/10.1557/s43579-026-01033-7.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, CB1 0AS UK.",
    "Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 USA.",
    "Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ UK.",
    "Department of Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong China.",
    "Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ UK.",
    "Department of Neurosurgery, Houston Methodist, Houston, TX 77030 USA.",
    "Neuroengineering Initiative, Rice University, Houston, TX 77030 USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Alexander J Boys",
      "orcid": "0000-0002-6488-7005"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Alejandro Carnicer Lombarte"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Salim El-Hadwe"
    },
    {
      "affs": [
        2
      ],
      "name": "Sam Hilton"
    },
    {
      "affs": [
        2
      ],
      "name": "Chaeyeon Lee"
    },
    {
      "affs": [
        2
      ],
      "name": "Filip Wronowski"
    },
    {
      "affs": [
        2
      ],
      "name": "Tobias E Naegele"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana Fernandez-Villegas"
    },
    {
      "affs": [
        2,
        4,
        5,
        6
      ],
      "name": "Damiano G Barone"
    },
    {
      "affs": [
        0
      ],
      "name": "Gabriele S Kaminski Scherle"
    },
    {
      "affs": [
        2
      ],
      "name": "George G Malliaras",
      "orcid": "0000-0002-4582-8501"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bc2wzj89wzt38.bib",
  "cited_by": 0,
  "doi": "10.1557/s43579-026-01033-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13743597",
  "id": "bc2wzj89wzt38",
  "issns": [
    "2159-6859",
    "2159-6867"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999435",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Early Career Materials Researcher Methods Letter"
    ],
    [
      "openalex",
      "2804|Neuroscience and Neural Engineering"
    ]
  ],
  "openalex": "W7203791864",
  "pdf_url": "https://europepmc.org/articles/PMC13743597?pdf=render",
  "pmcid": "PMC13743597",
  "pmid": "42999435",
  "published": "2026-08-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bc2wzj89wzt38.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:42Z",
      "native_id": "MED:42999435",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999435"
    },
    {
      "first_seen": "2026-11-11T12:21:16Z",
      "native_id": "PMC13743597",
      "source": "pmc",
      "url": "https://doi.org/10.1557/s43579-026-01033-7"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Neuroscience and Neural Engineering",
      "subfield": "neuroscience"
    }
  ],
  "title": "Cellularized, needle-deployed intracortical arrays for brain electrophysiology.",
  "title_text": "Cellularized, needle-deployed intracortical arrays for brain electrophysiology.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-11T12:21:16Z",
  "url": "https://research.draconitic.com/paper/bc2wzj89wzt38",
  "venue": "MRS communications",
  "versions": []
}