{
  "abstract": "BackgroundCOVID-19 has had a substantial burden on older adults aged 65+. This studys objective was to evaluate inpatient mortality among hospitalized Fee-for-Service (FFS) Medicare beneficiaries ages 65+ with COVID-19 treated with COVID-19 convalescent plasma (CCP) during August 2020-December 2021: overall, monthly, and by patient and hospital characteristics.\n\nStudy Design and MethodsOur retrospective claims-based study utilized large Centers for Medicare & Medicaid Services administrative databases to assess inpatient COVID-19 stays with recorded CCP transfusions among FFS Medicare beneficiaries ages 65+. CCP transfusions were identified by recorded procedure codes, and inpatient mortality via the patient status discharge code. Crude inpatient mortality rates (per 100 CCP transfusion stays with COVID-19) and corresponding 95% confidence intervals were evaluated across a range of patient and hospital characteristics. Multivariate logistic regression analyses were used to assess potential risk factors.\n\nResultsThe overall crude inpatient mortality was 25.5% (95%CI:25.2%-25.8%), declining from 30.7% (95%CI:29.1%-32.3%) in August 2020 to 7.4% (95%CI:3.8%-15.0%) in December 2021, p<0.001. The study identified significantly higher adjusted odds of inpatient mortality for each year of advancing age (1.06; 95%CI:1.06-1.07), immunocompromised (IC) vs. non-IC (1.14; 95%CI:1.05-1.24), males vs. females (1.20; 95%CI:1.15-1.25), Medicaid-eligible vs. not (1.13; 95%CI:1.07-1.20), medium (1.14; 95%CI:1.06-1.22) and large (1.09; 95%CI:1.01-1.19) compared to small hospitals, with ICU/CCU admission vs. not (2.71; 95%CI:2.57-2.85), mechanical ventilation<96 hours (13.11; 95%CI:12.11-14.20) and [≥]96 hours (11.59; 95%CI:10.89-12.34) vs. not, among others.\n\nDiscussionThe findings highlight importance of patient and hospital characteristics, including demographics, comorbidities, socioeconomic status, and COVID-19 severity, for inpatient mortality among Medicare beneficiaries receiving CCP.",
  "abstract_shown": true,
  "affiliations": [
    "FDA/CBER"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "M. Menis"
    },
    {
      "name": "N. Duma"
    },
    {
      "name": "S. Barney"
    },
    {
      "name": "Y. Chillarige"
    },
    {
      "name": "W. R. Steele"
    },
    {
      "name": "S. H. Chang"
    },
    {
      "name": "C. H. Villa"
    },
    {
      "name": "A. F. Eder"
    },
    {
      "name": "B. I. Whitaker"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bc2yw7ywv2n0v.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.22.26365943",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.22.26365943v1.full",
  "id": "bc2yw7ywv2n0v",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.22.26365943v1",
  "language": null,
  "licence": "CC0-1.0",
  "licence_label": "CC0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/publicdomain/zero/1.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "epidemiology"
    ],
    [
      "openalex",
      "2725|COVID-19 Clinical Research Studies"
    ]
  ],
  "openalex": "W7223706157",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.22.26365943v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bc2yw7ywv2n0v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:47Z",
      "native_id": "10.64898/2026.10.22.26365943",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.22.26365943v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:epidemiology",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Inpatient Mortality and Risk Factors Among Hospitalized Medicare Beneficiaries Ages 65 and Older with COVID-19 Treated with COVID-19 Convalescent Plasma (CCP), During 2020-2021",
  "title_text": "Inpatient Mortality and Risk Factors Among Hospitalized Medicare Beneficiaries Ages 65 and Older with COVID-19 Treated with COVID-19 Convalescent Plasma (CCP), During 2020-2021",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:47Z",
  "url": "https://research.draconitic.com/paper/bc2yw7ywv2n0v",
  "venue": "medRxiv",
  "versions": []
}