{
  "abstract": "Background/Objectives: To determine the proportion of elderly-onset sarcoidosis (EOS) and to assess the influence of age at diagnosis on pulmonary and extrapulmonary manifestations. Methods: Retrospective multicentre study using the Spanish SARCOGEAS registry, including adults with sarcoidosis diagnosed across 36 hospitals. EOS was defined as diagnosis at ≥65 years. Associations between clinical features and age were assessed using multivariable logistic and linear regression models, including sex-stratified analyses. Results: Among 2187 patients (mean age 48.6 ± 15.2 years, 61.36% women), 358 (16.37%) had EOS. In multivariable analyses, female sex (OR 1.86; β +5.02 years), White ethnicity (OR 5.43; β +4.85 years), and renal involvement (OR 2.29; β +6.86 years) were independently associated with EOS and older age at diagnosis, whereas cutaneous (OR 0.49; β −3.50 years), articular or bone (OR 0.37; β −3.10 years), and neurological involvement (OR 0.49; β −2.47 years) were associated with non-EOS and younger age at diagnosis. Exploratory sex-stratified analyses suggested additional patterns: in women, calcium metabolism abnormalities were associated with EOS (OR 1.74) and older age at diagnosis (β +4.91 years), and ear–nose–throat involvement was associated with older age at diagnosis (β +5.74 years). Regarding pulmonary involvement, CT-based Scadding stage II was associated with younger age at diagnosis (β −3.75 years) in women and CT-based Scadding stage IV with older age at diagnosis (β +6.57 years) in men. Conclusions: EOS accounted for 16.37% of sarcoidosis cases. Older age at diagnosis was associated with specific patterns of organ involvement, which changed gradually across the age spectrum, some of them differing by sex in exploratory analyses. Further studies are needed to confirm these findings.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, 08208 Sabadell, Spain",
    "Department of Autoimmune Diseases, ICMiD, Hospital Clínic, 08036 Barcelona, Spain",
    "Department of Internal Medicine, Hospital Universitari Doctor Josep Trueta, IDIBGI, 17007 Girona, Spain",
    "Department of Internal Medicine, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain",
    "Department of Internal Medicine, Hospital Clínico, 50009 Zaragoza, Spain",
    "Department of Internal Medicine, Hospital Joan XXIII, 43005 Tarragona, Spain",
    "Department of Internal Medicine, Hospital Santa Caterina, 17190 Salt, Spain",
    "Department of Internal Medicine, Hospital de Cabueñes, 33394 Gijón, Spain",
    "Department of Internal Medicine, Hospital Ramón y Cajal, 28034 Madrid, Spain",
    "Department of Internal Medicine, Hospital CIMA Sanitas, 08034 Barcelona, Spain",
    "Department of Internal Medicine, Hospital Virgen del Rocío, 41013 Sevilla, Spain",
    "Department of Internal Medicine, Hospital Virgen de la Salud, 45004 Toledo, Spain",
    "Department of Internal Medicine, Hospital Universitario La Paz, 28046 Madrid, Spain",
    "Department of Internal Medicine, Althaia, Xarxa Assistencial de Manresa, 08243 Manresa, Spain",
    "Department of Internal Medicine, Hospital Gregorio Marañón, 28007 Madrid, Spain",
    "Department of Internal Medicine, Hospital General Universitario de Salamanca-IBSAL, Universidad de Salamanca, 37007 Salamanca, Spain",
    "Department of Internal Medicine, Hospital 12 de Octubre, 28041 Madrid, Spain",
    "Department of Internal Medicine, Hospital General Universitario de Alicante, 03010 Alicante, Spain",
    "Department of Internal Medicine, Hospital Infanta Leonor, 28031 Madrid, Spain",
    "Department of Medicine, Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08036 Barcelona, Spain"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "María García-González",
      "orcid": "0009-0000-7396-1089"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlos Feijoo-Massó",
      "orcid": "0000-0003-4251-1194"
    },
    {
      "affs": [
        1
      ],
      "name": "Alejandra Flores-Chávez"
    },
    {
      "affs": [
        2
      ],
      "name": "Guillem Policarpo-Torres",
      "orcid": "0000-0002-5404-4944"
    },
    {
      "affs": [
        3
      ],
      "name": "Ricardo Gómez de la Torre"
    },
    {
      "affs": [
        4
      ],
      "name": "Begoña de Escalante Yangüela",
      "orcid": "0000-0002-9648-1456"
    },
    {
      "affs": [
        5
      ],
      "name": "Jesús Miguel López-Dupla",
      "orcid": "0000-0002-9141-2523"
    },
    {
      "affs": [
        6
      ],
      "name": "Cristina Soler-I-Ferrer"
    },
    {
      "affs": [
        7
      ],
      "name": "Eva Fonseca-Aizpuru",
      "orcid": "0000-0003-0578-7474"
    },
    {
      "affs": [
        8
      ],
      "name": "Andrés González-García"
    },
    {
      "affs": [
        9
      ],
      "name": "Rosana Rouco"
    },
    {
      "affs": [
        10
      ],
      "name": "Salvador García Morillo"
    },
    {
      "affs": [
        11
      ],
      "name": "Ana Alguacil"
    },
    {
      "affs": [
        12
      ],
      "name": "Ana Noblejas-Mozo",
      "orcid": "0000-0003-1282-6515"
    },
    {
      "affs": [
        13
      ],
      "name": "Mariona Bonet"
    },
    {
      "affs": [
        14
      ],
      "name": "María Barrientos"
    },
    {
      "affs": [
        15
      ],
      "name": "Antonio-J. Chamorro",
      "orcid": "0000-0002-2345-2873"
    },
    {
      "affs": [
        16
      ],
      "name": "Borja De Miguel-Campo"
    },
    {
      "affs": [
        17
      ],
      "name": "Maria Gracia Cruz Caparrós"
    },
    {
      "affs": [
        18
      ],
      "name": "Miriam Akasbi Montalvo",
      "orcid": "0000-0001-5888-4409"
    },
    {
      "affs": [
        0
      ],
      "name": "Alex Mayer-Fuentes"
    },
    {
      "affs": [
        1,
        19
      ],
      "name": "Manuel Ramos-Casals",
      "orcid": "0000-0001-5709-6734"
    },
    {
      "affs": [
        9
      ],
      "name": "Pilar Brito-Zerón"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bc9w18zzng84x.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218355",
  "fulltext_url": null,
  "id": "bc9w18zzng84x",
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    "2077-0383"
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  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Sarcoidosis and Beryllium Toxicity Research"
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  "openalex": "W7224012419",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/bc9w18zzng84x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15218355",
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      "url": "https://www.mdpi.com/2077-0383/15/21/8355"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Sarcoidosis and Beryllium Toxicity Research",
      "subfield": "physiology"
    }
  ],
  "title": "Elderly-Onset Sarcoidosis and the Influence of Age on Clinical Phenotypes: A Multicentre Analysis from the SARCOGEAS Registry",
  "title_text": "Elderly-Onset Sarcoidosis and the Influence of Age on Clinical Phenotypes: A Multicentre Analysis from the SARCOGEAS Registry",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:01Z",
  "url": "https://research.draconitic.com/paper/bc9w18zzng84x",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}