{
  "abstract": "Transcriptional repression is a central mechanism regulating plant growth and development, yet how plant-specific corepressors achieve robust gene silencing remains unclear. Here, we identify the rice corepressor TPR2 (TOPLESS-RELATED 2) as a phaseseparating protein that forms nuclear condensates through the cooperative action of an intrinsically disordered region (IDR1) and a plant-specific N-terminal tetramerization domain. Structure-guided mutagenesis disrupting tetramerization or deleting IDR1 markedly impaired condensate formation in vivo and in vitro. Complementation assays showed that only full-length TPR2, capable of robust condensate formation, rescued the growth defects of the tpr2 mutant, whereas phase separation-deficient variants failed to do so. Mechanistically, we demonstrate that TPR2 co-condenses with repressors such as D53 and IAA3 to facilitate histone deacetylation and establish repressive chromatin states in a phase separation-dependent manner, thereby fine-tuning key developmental genes. Together, these findings define a condensate-based mechanism for transcriptional repression in plants, linking corepressor phase separation to chromatin modification, gene silencing and developmental control.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "name": "Yu Zhang"
    },
    {
      "name": "Bingchen Li"
    },
    {
      "name": "Yu Chen"
    },
    {
      "name": "Jiawei Li"
    },
    {
      "name": "Yao Wang"
    },
    {
      "name": "Tiantian Ye"
    },
    {
      "name": "Ying Ye"
    },
    {
      "name": "Zhiwei Liu"
    },
    {
      "name": "Zhiyue Feng"
    },
    {
      "name": "Stephanie Hutin"
    },
    {
      "name": "Shaoli Zhou"
    },
    {
      "name": "Jianping Guo"
    },
    {
      "name": "Ruihui Zhang"
    },
    {
      "name": "Zhu Liu"
    },
    {
      "name": "Faming Dong"
    },
    {
      "name": "Haiyan Xiong"
    },
    {
      "name": "Chloe Zubieta"
    },
    {
      "name": "Lizhong Xiong"
    },
    {
      "name": "Xuelei Lai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bctbzbptb8e8j.bib",
  "cited_by": 0,
  "doi": "10.1038/s44318-026-00852-7",
  "fulltext_url": null,
  "id": "bctbzbptb8e8j",
  "issns": [
    "0261-4189",
    "1460-2075"
  ],
  "landing_url": "https://hal.inrae.fr/hal-05760455v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1110|Plant Molecular Biology Research"
    ]
  ],
  "openalex": "W7167480406",
  "pdf_url": "https://hal.inrae.fr/hal-05760455/document",
  "pmcid": null,
  "pmid": "42410257",
  "published": "2026-07-06",
  "publisher": "Springer nature",
  "ris": "https://research.draconitic.com/paper/bctbzbptb8e8j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "hal-05760455",
      "source": "hal",
      "url": "https://hal.inrae.fr/hal-05760455v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant Molecular Biology Research",
      "subfield": "plant-biology"
    }
  ],
  "title": "The TPR2 corepressor forms condensates with repressors to fine-tune growth and development in rice",
  "title_text": "The TPR2 corepressor forms condensates with repressors to fine-tune growth and development in rice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/bctbzbptb8e8j",
  "venue": "The EMBO Journal",
  "versions": []
}