{
  "abstract": "Background/Objectives: Fasting blood glucose (FBG) and stent count have been associated with in-stent restenosis (ISR), but their interrelationships remain unclear. We evaluated the FBG–ISR association and explored baseline stent count as a potential mediator. Methods: This single-center retrospective cohort comprised 510 patients with follow-up angiography after percutaneous coronary intervention (PCI). Analyses included multivariable regression, exploratory decomposition in 468 patients sampled before PCI, and intravascular imaging analyses in 284 patients. Results: ISR was observed in 56 patients (11.0%). The adjusted FBG–ISR odds ratio (OR) was 1.100 per mmol/L (95% confidence interval [CI] 1.001–1.208; p = 0.048); Firth and diabetes-adjusted CIs included 1. For FBG increasing from 5.07 to 7.59 mmol/L, the indirect component associated with baseline stent count was 0.48 percentage points (95% CI 0.06 to 1.05); the direct and total CIs included zero. Exploratory analyses suggested higher direct-effect estimates in men and positive indirect-effect estimates in women; between-sex indirect differences remained uncertain. Higher stent count was associated with underexpansion, which was associated with ISR (adjusted OR 4.47, 95% CI 1.85–10.78). Conclusions: Higher FBG showed a modest positive association with ISR, with uncertainty across sensitivity analyses. Exploratory analyses yielded a positive indirect estimate for stent count and linked underexpansion to ISR.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuan Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan Zhuang"
    },
    {
      "affs": [
        0
      ],
      "name": "Liao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiyan Song"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bd5c6n4mx9200.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218685",
  "fulltext_url": null,
  "id": "bd5c6n4mx9200",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8685",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-07",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/bd5c6n4mx9200.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:41Z",
      "native_id": "10.3390/jcm15218685",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8685"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Glycemic Status, Stent Count, and In-Stent Restenosis: Exploratory Decomposition and Sex-Related Analyses in a Retrospective Cohort",
  "title_text": "Glycemic Status, Stent Count, and In-Stent Restenosis: Exploratory Decomposition and Sex-Related Analyses in a Retrospective Cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:41Z",
  "url": "https://research.draconitic.com/paper/bd5c6n4mx9200",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}