{
  "abstract": "Arg-Gly-Asp peptide (RGD) binds to α v β ₃ integrins, which are involved in the development of new vessels, necessary for tumor growth. Several RGD-based PET radiopharmaceuticals have been developed to visualize integrin α v β ₃ expression. Differences between O-(2-[ ¹⁸ F]-fluoroethyl)-L-tyrosine ([ ¹⁸ F]FET) and integrin-targeting radiopharmaceuticals in patients with brain tumors have not been evaluated so far. Our aim was to compare the diagnostic information provided by the α v β ₃ integrin-targeting [ ⁶⁸ Ga]Ga-NODAGA-RGDyK ([ ⁶⁸ Ga]Ga-RGD) with that of [ ¹⁸ F]FET and contrast-enhanced T1-weighted sequences (CE-T1w) in 10 patients with newly diagnosed or recurrent diffuse glioma. After image registration, tumor segmentation of [ ⁶⁸ Ga]Ga-RGD and [ ¹⁸ F]FET PET images was performed using the average background signal multiplied by 1.6 as a threshold for positivity. The contrast-enhancing tumor portions were manually delineated on CE-T1w sequences. Tumor volumes (TV) identified by all three modalities (i.e. TV RGD , TV FET , TV CE−T1w ) were compared and their spatial congruence (SC) calculated. Thirteen brain lesions from 10 patients ( n = 4 with high-grade gliomas and n = 6 with low-grade gliomas) were analyzed, all showing increased [ ¹⁸ F]FET uptake. Nine lesions were [ ⁶⁸ Ga]Ga-RGD-positive, 4 were [ ⁶⁸ Ga]Ga-RGD-negative, all corresponding to non-contrast enhancing lesions. Tumor-to-background ratios (TBR) were higher for [ ⁶⁸ Ga]Ga-RGD-positive than for [ ¹⁸ F]FET -positive disease (median TBR = 3.92 vs. 2.12, respectively, p = 0.008). All [ ¹⁸ F]FET - and [ ⁶⁸ Ga]Ga-RGD-positive lesions extended beyond the contrast-enhancing tumor portions. In the whole cohort, TV FET exceeded TV RGD (median values = 11.2 vs. 7.7 mL, p = 0.014). In most high-grade glioma lesions (i.e. 5/7), however, TV RGD was larger than TV FET . Overall, median overlapping volume between [ ⁶⁸ Ga]Ga-RGD and [ ¹⁸ F]FET was 3.6 mL (range 0.1–8.13mL), and the median SC was 24.3% (range, 0.9–59.8%). [ ¹⁸ F]FET and [ ⁶⁸ Ga]Ga-RGD PET provide different information. In the overall cohort, TV FET was larger than TV RGD , however TV RGD tended to be larger than TV FET in the subgroup of patients with high-grade glioma. [ ⁶⁸ Ga]Ga-RGD PET may delineate regions of active neoangiogenesis extending beyond gadolinium enhancement.\n\nTrial registration : https://www.clinicaltrials.gov/study/NCT02666547 , registered 2012-08-12.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Nathalie Testart Dardel",
      "orcid": "0000-0002-1556-5771"
    },
    {
      "name": "Silvano Gnesin",
      "orcid": "0000-0002-6547-3824"
    },
    {
      "name": "Vincent Dunet",
      "orcid": "0000-0002-9897-4561"
    },
    {
      "name": "Luis Schiappacasse",
      "orcid": "0000-0001-7621-1662"
    },
    {
      "name": "Daniela Ferraro",
      "orcid": "0009-0001-7033-6023"
    },
    {
      "name": "Rita De Micheli"
    },
    {
      "name": "Monika E. Hegi",
      "orcid": "0000-0003-0855-6495"
    },
    {
      "name": "Andreas F. Hottinger",
      "orcid": "0000-0001-7098-9414"
    },
    {
      "name": "John O. Prior",
      "orcid": "0000-0003-1429-1374"
    },
    {
      "name": "Francesco Cicone",
      "orcid": "0000-0003-4664-1965"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bdbzpmrbj9rrq.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-74657-3",
  "fulltext_url": null,
  "id": "bdbzpmrbj9rrq",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-74657-3",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Medical Imaging Techniques and Applications"
    ]
  ],
  "openalex": "W7221002750",
  "pdf_url": "https://www.nature.com/articles/s41598-026-74657-3_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/bdbzpmrbj9rrq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1038/s41598-026-74657-3",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-74657-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Medical Imaging Techniques and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "Comparison between [68Ga]Ga-NODAGA-RGDyK and [18F]FET for the assessment of gliomas: results of a pilot study",
  "title_text": "Comparison between [68Ga]Ga-NODAGA-RGDyK and [18F]FET for the assessment of gliomas: results of a pilot study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/bdbzpmrbj9rrq",
  "venue": "Scientific Reports",
  "versions": []
}