{
  "abstract": "Deoxynivalenol (DON) is a common mycotoxin contaminating poultry feed, which can induce oxidative stress, immune disorders and barrier damage in the intestinal tract of broilers, seriously affecting performance and feed safety. Rosa roxburghii Tratt polysaccharides (RRTPs), a characteristic wild plant resource, have been reported to have antioxidant and immunomodulatory activities. However, whether RRTPs can effectively combat DON induced intestinal disorders in broilers has not been systematically studied. In this study, one-day-old male broilers were acclimated for 3 days and then subjected to dietary supplementation with RRTPs (100, 200, and 400 mg/kg diet) under normal conditions or combined with DON exposure (4 mg/kg diet) for 42 days to evaluate the protective effects of RRTPs against DON-associated intestinal injury. The results showed that under normal physiological conditions, RRTPs could improve body weight gain and feed efficiency, up-regulate the expression of tight junction proteins, modulate jejunal microbiota composition without significantly altering microbial diversity, and enhance mucosal innate immune defense. Under DON exposure, RRTPs significantly reduced the contents of intestinal reactive oxygen species and malondialdehyde, restored the total antioxidant capacity and mitochondrial DNA content, inhibited cGAS-STING-related signaling responses, and regulated the expression of markers associated with M1/M2 macrophages. In summary, RRTPs supplementation alleviated DON-associated intestinal injury by improving redox status and immune-related responses, providing insights into the potential application of Rosa roxburghii Tratt polysaccharides in mycotoxin risk mitigation.",
  "abstract_shown": true,
  "affiliations": [
    "College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China",
    "Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China",
    "Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xinbo Wang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yichao Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jinwen Ge"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Pengli Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Guodong Cai"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ruilong Song"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Hui Zou"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jianhong Gu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yan Yuan"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xuezhong Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Zongping Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jianchun Bian"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bdfhg9fmgtc0h.bib",
  "cited_by": 0,
  "doi": "10.1016/j.psj.2026.108035",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735231/",
  "id": "bdfhg9fmgtc0h",
  "issns": [
    "0032-5791",
    "1525-3171"
  ],
  "landing_url": "https://doi.org/10.1016/j.psj.2026.108035",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Full-Length Article"
    ],
    [
      "openalex",
      "1110|Mycotoxins in Agriculture and Food"
    ]
  ],
  "openalex": "W7223463515",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S003257912601669X/pdf",
  "pmcid": "PMC13735231",
  "pmid": "42945835",
  "published": "2026-10-24",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/bdfhg9fmgtc0h.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:57Z",
      "native_id": "PMC13735231",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.psj.2026.108035"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Mycotoxins in Agriculture and Food",
      "subfield": "plant-biology"
    }
  ],
  "title": "Dietary Rosa roxburghii Tratt polysaccharides improve intestinal health and alleviate deoxynivalenol-induced oxidative stress and immune imbalance in broilers",
  "title_text": "Dietary Rosa roxburghii Tratt polysaccharides improve intestinal health and alleviate deoxynivalenol-induced oxidative stress and immune imbalance in broilers",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:57Z",
  "url": "https://research.draconitic.com/paper/bdfhg9fmgtc0h",
  "venue": "Poultry Science",
  "versions": []
}