{
  "abstract": "目的探讨帕金森病（PD）患者合并快速眼动睡眠行为障碍（RBD）的血浆Ser129位点磷酸化α-突触核蛋白（p-α-syn）水平与睡眠质量的关联。方法收集2024年1月至2025年12月就诊的PD患者（伴RBD者51例和不伴RBD者59例）和50名健康人。采用帕金森病统一评分量表第Ⅲ部分（UPDRSⅢ）对运动状况评估，采用帕金森病生活质量量表（PDQ-39）评价生活质量，蒙特利尔认知评估量表（MOCA）评价认知，快速眼动睡眠行为障碍筛查问卷（RBDSQ）、爱泼沃斯嗜睡量表（ESS）、PD睡眠量表第2版（PDSS-2）和匹兹堡睡眠质量指数量表（PSQI）评估睡眠情况。多重Luminex液相芯片技术检测血浆p-α-syn、白介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、干扰素-γ、免疫球蛋白（Ig）G、IgA、IgM。结果PD-RBD患者血浆p-α-syn高于健康对照组（P<0.05）。PD患者血浆IL-1β及TNF-α含量升高，血浆IgG含量降低（P<0.05）；UPDRS Ⅲ评分与p-α-syn含量及睡眠碎片度成正比（P<0.05）。结论PD-RBD患者血浆p-α-syn（Ser129）的水平与患者的睡眠碎片有关，可作为PD-RBD患者睡眠碎片的生物标记物。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "孟猛"
    },
    {
      "name": "李红星"
    },
    {
      "name": "李建"
    },
    {
      "name": "刘露"
    },
    {
      "name": "蔚红霞"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bdz85vmnnbd15.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.001",
  "id": "bdz85vmnnbd15",
  "issns": [
    "1007-4287"
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  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.001",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/bdz85vmnnbd15.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:46Z",
      "native_id": "99f69ab2ecfd4973a7679fe67f11f553",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.001"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "帕金森病伴快速眼动睡眠行为障碍患者磷酸化α-突触核蛋白水平与睡眠片段化程度的关联研究",
  "title_text": "帕金森病伴快速眼动睡眠行为障碍患者磷酸化α-突触核蛋白水平与睡眠片段化程度的关联研究",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:46Z",
  "url": "https://research.draconitic.com/paper/bdz85vmnnbd15",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}